中国医院用药评价与分析2017，Vol.17Issue(11)：1496-1498,3.DOI:10.14009/j.issn.1672-2124.2017.11.018
神经节苷脂对结肠癌患者含奥沙利铂化疗方案致周围神经毒性的疗效观察
Observation on Efficacy of Gangliosides in Application of Chemotherapy Regimen of Oxaliplatin in Treatment of Peripheral Neurotoxicity Among Patients with Colon Cancer
谢建立 1冯丽娟2
作者信息
- 1. 佛山市高明区人民医院肿瘤科,广东佛山 528500
- 2. 佛山市顺德区北滘医院药剂科,广东佛山 528311
- 折叠
摘要
Abstract
OBJECTIVE: To probe into the efficacy of gangliosides in application of chemotherapy regimen of oxaliplatin in treatment of peripheral neurotoxicity among patients with colon cancer .METHODS: 60 patients with colon cancer were selected and divided into observation group and control group via random number table , with 30 cases in each.Both groups were treated with oxaliplatin +calcium folinate +5-fluorouracil or oxaliplatin +capecitabine .The control group was given reduced glutathione injection for intravenous drip at the first day of each chemotherapy course for 0.3 g once a day , with continuous administration of 14 days;the observation group was given monosialotetrahexosyl ganglioside sodium injection for intravenous drip at the first day of each chemotherapy course for 20 mg once a day, with continuous administration of 14 days.21 days were set as a chemotherapy course for each group .Peripheral neurotoxicity and other adverse drug reactions of two groups were observed , and the difference of efficacy between two groups were compared . RESULTS: During chemotherapy , the incidences of peripheral neurotoxicity of observation group (70.00％, 21/30) was significantly lower than that of the control group (83.33％, 25/30 ) , with statistically significant difference ( P<0.05 );no Ⅳ level of peripheral neurotoxicity was found in both groups , the incidence of Ⅱ level and Ⅲ level of peripheral neurotoxicity of observation group was significantly lower than that of the control group , with statistically significant difference ( P<0.05 );there was no statistical significance in difference of other incidences of adverse drug reactions between two groups ( P>0.05 ); there was no statistical significance in differences of the objective remission rates and disease control rates between two groups ( P>0.05 ) . CONCLUSIONS: Gangliosides can reduce the incidence of peripheral neurotoxicity in chemotherapy regimen of oxaliplatin among patients with colon cancer , and relieve the peripheral neurotoxic response intensity .关键词
神经节苷脂/奥沙利铂/结肠癌/周围神经毒性Key words
Gangliosides/Oxaliplatin/Colon cancer/Peripheral neurotoxicity分类
医药卫生引用本文复制引用
谢建立,冯丽娟..神经节苷脂对结肠癌患者含奥沙利铂化疗方案致周围神经毒性的疗效观察[J].中国医院用药评价与分析,2017,17(11):1496-1498,3.
