中国中医药信息杂志2018，Vol.25Issue(1)：79-83,5.DOI:10.3969/j.issn.1005-5304.2018.01.017
糖网明目颗粒喷雾制粒工艺参数优选及其颗粒性状研究
Optimization of Parameters of Granule Spray Process of Tangwang Mingmu Granules and Study on Its Grain Properties
摘要
Abstract
Objective To select the optimum process of granule spray for Tangwang Mingmu Granules, To improve the yield and finished product quality. Methods The effects of the relative density, the type of excipients, the ratio of the extract and the excipient, the inlet temperature-the material temperature, the spray rate and the atomization pressure were selected by single factor and orthogonal test respectively to determine the optimum preparation process. Validation for three batch sample, particle flow, hygroscopicity and other related content of the preparation were studied. Results The optimum spray granulation process of Tangwang Mingmu Granules: the relative density of extract (60 ℃ determination) was 1.15–1.20; the excipient was selected as dextrin; the ratio of dry extract and excipient was 58:42; inlet temperature - material temperature was 90-75 ℃; atomization pressure was 0.12 mPa;spray rate was 10 Hz.Conclusion The preparation technology of Tangwang Mingmu Granules optimized in this study is with high preparation rate, good fluidity and hygroscopicity, which can be used for the preparation of Tangwang Mingmu Granules.关键词
糖网明目颗粒/喷雾制粒/制粒工艺Key words
Tangwang Mingmu Granules/spray granulation/granulation process分类
医药卫生引用本文复制引用
张桂杰,陈明霞,宋晓莉,刘晔,康东周,连增林..糖网明目颗粒喷雾制粒工艺参数优选及其颗粒性状研究[J].中国中医药信息杂志,2018,25(1):79-83,5.基金项目
北京市科技计划"十病十药"中药专项(Z121102001112007) （Z121102001112007）
