中国卒中杂志2017，Vol.12Issue(12)：1081-1085,5.DOI:10.3969/j.issn.1673-5765.2017.12.003
血清Hcy和hs-CRP与缺血性卒中各亚型关系的临床研究
Clinical Study on Correlation between Levels of Serum Homocysteine, High Sensitivity C-reactive Protein and Subtypes of Ischemic Stroke
摘要
Abstract
Objective To investigate the differences of homocysteine (Hcy), high sensitivity C-reactive protein (hs-CRP) on large-artery atherosclerosis and small vessel occlusive ischemic stroke (IS), and the association between the two and complete IS and progressive IS. Methods A total of 217 participants with large-artery atherosclerosis (LAA) ischemic stroke (n=130) and small artery occlusive (SAO) ischemic stroke (n=87) based on trial of org 10 172 in acute stroke treatment (TOAST) were recruited in this study. The cases number of progressive stroke (PS) in LAA group and SAO group were 58 and 12 respectively. The level of serum Hcy and hs-CRP contents were measured and compared between two groups. Results (1) Hcy (P<0.019), hs-CRP (P=0.021), and low density lipoprotein (LDL) (P=0.012) were significantly different in the LAA and SAO groups by logistic regression analysis, and the levels of serum Hcy, hs-CRP and LDL in the LAA stroke group were significantly higher than those in the SAO group. (2) There were significant difference in Hcy (P<0.001), hs-CRP (P=0.017) and LAA (P=0.023) after correction of mixed factors in progressive and complete stroke, and serum levels of Hcy, hs-CRP and LAA were significantly higher in all patients with progressive stroke than those with complete stroke. (3) There were no significant difference in the levels of Hcy between PS and complete stroke in LAA, while the levels of hs-CRP were higher in PS. Conclusion Hcy, hs-CRP and LDL are the independent risk factors of LAA stroke. Hcy, hs-CRP, and LDL can be used as one of the indicators of IS classification. Hcy, hs-CRP and LAA are the independent risk factors of PS.关键词
缺血性卒中/大动脉粥样硬化型/超敏C-反应蛋白/同型半胱氨酸/进展性卒中Key words
Ischemic stroke/Large-artery atherosclerosis/High-sensitivity C-reactive protein/Homocysteine/Progressive stroke引用本文复制引用
郭振方,王桂华,贵永堃,王昊亮,闫海清,张平..血清Hcy和hs-CRP与缺血性卒中各亚型关系的临床研究[J].中国卒中杂志,2017,12(12):1081-1085,5.基金项目
河南省卫生厅科技攻关项目(2011020094) （2011020094）
