肿瘤防治研究2017，Vol.44Issue(12)：796-803,8.DOI:10.3971/j.issn.1000-8578.2017.17.0563
细胞减灭术加腹腔热灌注化疗治疗胃癌腹膜癌的系统分析
Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy on Gastric Cancer Peritoneal Carcinomatosis: A Systemic Analysis
摘要
Abstract
Objective To evaluate the clinical trials of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) on gastric cancer peritoneal carcinomatosis (GC PC).Methods The published clinical trials of CRS+HIPEC on GC PC were critically evaluated,with survival and safety as the primary endpoints.Results The natural course of GC PC was ＜ 5 months.CRS+HIPEC could improve the overall survival (OS).In prospective studies,the median OS was 11.0 months in the CRS+HIPEC group.In retrospective studies,the median OS was 13.3 months in the CRS+HIPEC group.The perioperative mortality was less than 6.5％,and there was no statistically significant increase in serious adverse events directly attributable to CRS+HIPEC.Conclusion CRS+HIPEC is a promising integrated treatment strategy for GC PC to produce improved treatment efficacy,and should be recommended as the first treatment choice for selected patients with GC PC.关键词
胃癌/腹膜癌/临床试验/细胞减灭术/腹腔热灌注化疗Key words
Gastric cancer/Peritoneal carcinomatosis/Clinical trials/Cytoreductive surgery(CRS)/Hyperthermic intraperitoneal chemotherapy (HIPEC)分类
医药卫生引用本文复制引用
姬忠贺,梁寒,季加孚,于洋,李鑫宝,李雁..细胞减灭术加腹腔热灌注化疗治疗胃癌腹膜癌的系统分析[J].肿瘤防治研究,2017,44(12):796-803,8.基金项目
首都临床特色应用研究与成果推广项目(Z161100000516077) （Z161100000516077）
北京市自然科学基金(7172108) （7172108）
首都医科大学附属北京世纪坛医院重点学科建设项目(2016fmzlwk) （2016fmzlwk）
