肿瘤防治研究2017，Vol.44Issue(12)：840-844,5.DOI:10.3971/j.issn.1000-8578.2017.17.0397
血小板新型活化受体CLEC-2和平足蛋白在肿瘤转移中的研究进展
Research Progress of New Platelet Receptor CLEC-2 and Podoplanin in Tumor Metastasis
摘要
Abstract
Podoplanin(PDPN),a type-Ⅰ transmembrane glycoprotein,was expressed in a variety of human tumor cells.C-type lectin-like receptor 2 (CLEC-2) is a type-Ⅱ transmembrane glycoprotein.It is a novel receptor for podoplanin,expresses on the surface of platelet and induces platelet activation by interacting with PDPN.Aggregated platelets coat tumor cells during their transit through the bloodstream and mediate adherence to vascular endothelium,evasion from immune molecules,and release of an array of bioactivc molecules that facilitate tumor cell extravasation and growth at metastatic sites.It suggests that PDPN and CLEC-2 are promising targets for developing new therapies against cancer metastasis.This review will focus on the mechanisms of PDPN and CLEC-2 in tumor metastasis,summarize and outlook the recent progress of treatment.关键词
平足蛋白/C型凝集素样受体2/肿瘤转移/血小板Key words
Podoplanin/CLEC-2/Tumor metastasis/Platelet分类
医药卫生引用本文复制引用
徐梦乔,赵益明..血小板新型活化受体CLEC-2和平足蛋白在肿瘤转移中的研究进展[J].肿瘤防治研究,2017,44(12):840-844,5.基金项目
国家自然科学基金(81270593) （81270593）
