海南医学院学报2017，Vol.23Issue(24)：3366-3369,4.DOI:10.13210/j.cnki.jhmu.20171208.009
水飞蓟宾联合垂体后叶素-酚妥拉明治疗肺结核合并急性咯血的疗效研究
The curative effect of silybin combined with pituitrin-phentolamine for pulmonary tuberculosis complicated by acute hemoptysis
摘要
Abstract
Objective:To study the curative effect of silybin combined with pituitrin-phentolamine for pulmonary tuber-culosis complicated by acute hemoptysis.Methods:78 patients with pulmonary tuberculosis complicated by acute hemoptysis who were treated in this hospital between December 2013 and April 2017 were divided into control group(n=39)and silybin group(n=39)by random number table.Control group received pituitrin-phentolamine hemostasis therapy,silybin group re-ceived pituitrin-phentolamine combined with silybin therapy,both were treated for 1 week.The differences in peripheral blood liver function and coagulation index levels as well as serum oxidative stress index contents were compared between the two groups of patients before treatment and after 1 week of treatment.Results:Before treatment,the differences in peripheral blood liver function and coagulation index levels as well as serum oxidative stress index contents were not statistically significant be-tween the two groups.After 1 week of treatment,peripheral blood liver function indexes ALT,AST,ALP and STB contents of silybin group were lower than those of control group;peripheral blood coagulation indexes PT,APTT and TT levels were lower than those of control group whereas Fib level was higher than that of control group;serum oxidative stress indexes AOPPs and LHP contents were lower than those of control group whereas GSH-Px and T-AOC contents were higher than those of control group.Conclusion:pituitrin-phentolamine combined with silybin therapy can effectively protect the liver func-tion,optimize the coagulation function and reduce the oxidative stress response in patients with pulmonary tuberculosis compli-cated by acute hemoptysis.关键词
肺结核/急性咯血/水飞蓟宾/垂体后叶素/酚妥拉明Key words
pulmonary tuberculosis/cute hemoptysis/silybin/pituitrin/phentolamine分类
医药卫生引用本文复制引用
李淑华,邹礼军..水飞蓟宾联合垂体后叶素-酚妥拉明治疗肺结核合并急性咯血的疗效研究[J].海南医学院学报,2017,23(24):3366-3369,4.基金项目
湖北省教育厅中青年人才项目(Q20151103)Hubei Provincial Education Hall youth talent project(Q20151103) （Q20151103）
