检验医学与临床2018，Vol.15Issue(1)：1-3,8,4.DOI:10.3969/j.issn.1672-9455.2018.01.001
乙型肝炎病毒感染者疾病进展程度与宿主CYP3A5和MDR1基因多态性研究
The association between the progression of hepatitis B patients and the genetic polymorphisms of CYP3A5 and MDR1
摘要
Abstract
Objective To explore the the progression of hepatitis B patients and the genetic polymorphisms of CYP3A5 and MDR1 .Methods The experimental subjects composed of 187 CHB patients ,163 hepatitis B-related cirrhosis ,174 hepatitis B-related hepatocelluar carcinomas .The genetic polymorphisms of CYP3A5 and MDR1 were analyzed by polymerase chain reaction and high resolution melting .Results The genetype of CYP3A5 and MDR1 was different in hepatitis B and disease progress group ,and the difference was statistically significant (P<0 .05) .Conclusion CYP3A5 and MDR1 may be related to progressive risk of HBV infection patients .CYP3A5 G and MDR1 C are protected genes in hepatitis B-infected patients .关键词
乙型肝炎/肝硬化/肝癌/CYP3A5基因/MDR1基因Key words
hepatitis B/cirrhosis/hepatocelluar carcinomas/CYP3A5/MDR1分类
医药卫生引用本文复制引用
杨旭洁,卢永杰,陈捷,吴晓娟,苏真珍,蔡蓓..乙型肝炎病毒感染者疾病进展程度与宿主CYP3A5和MDR1基因多态性研究[J].检验医学与临床,2018,15(1):1-3,8,4.基金项目
国家自然科学基金资助项目(81401666). （81401666）
