检验医学与临床2018，Vol.15Issue(1)：9-11,3.DOI:10.3969/j.issn.1672-9455.2018.01.003
1043例汉族双相情感障碍患者CYP2C19基因多态性及代谢表型分析
Analysis of CYP2C19 gene polymorphism and metabolic phenotype in 1043 bipolar disorder patients of Han nationality
摘要
Abstract
Objective To investigate the polymorphism of CYP2C19 gene and the distribution of metabolic phenotypes in bipolar disorder patients of Han nationality in Southern China ,and the relationship between sex and CYP2C19 gene polymorphism will be explored .Methods DNA microarray was used to detect the CYP2C19 gene polymorphism and metabolic phenotype in 1043 bipolar disorder patients ,gene counting meth-ods were used to calculate the genotype frequency and allele frequency ,and the relationship between different gender and the frequency of genetic polymorphism was analyzed .Results Six detected genotype(CYP2C191/1 ,1/2 ,1/3 ,2/2 ,2/3 ,3 /3 ) f requency w ere 40 .6％ ,40 .5％ ,5 .2％ ,9 .9％ ,3 .4％ , 0 .5％ ,the frequency of 3 metabolic phenotypes(extensive metabolizer ,intermediate metabolizer ,poor metabo-lizer) were 40 .5％ ,45 .8％ ,13 .7％ respectively .There was no significant difference in CYP2C19 genotype and metabolic phenotype between different gender groups .Conclusion 1/1 and 1/2 are the main poly-morphism of CYP2C19 in bipolar disorder patients of Han nationality ,681 loci′s mutation frequency is higher than that of 636 ,detection of the CYP2C19 gene polymorphism and metabolic phenotypes contribute to the clinical reasonable medication .关键词
双相情感障碍/CYP2C19基因多态性/代谢表型Key words
bipolar disorder/CYP2C19 gene polymorphism/metabolic phenotype分类
临床医学引用本文复制引用
徐鹏,胡国艳,邱萍英,何柯新,洪剑浩,林裕龙..1043例汉族双相情感障碍患者CYP2C19基因多态性及代谢表型分析[J].检验医学与临床,2018,15(1):9-11,3.基金项目
广东省科技计划资助项目(2016A020215022). （2016A020215022）
