检验医学与临床2018，Vol.15Issue(1)：12-15,4.DOI:10.3969/j.issn.1672-9455.2018.01.004
子痫前期患者A-FABP表达水平与胰岛素抵抗相关性研究
Study on the correlation between expression level of A-FABP and insulin-resistance in the patients with preeclampsia
摘要
Abstract
Objective To explore the relationship between the level of A-FABP and HOMA-IR in the pa-tients with preeclampsia and the pathogenesis of preeclampsia .Methods Seventy-six pregnancies diagnosed with preeclampsia in obstetrical department from october 2013 to october 2015 were selected as preeclampsia (42 cases of mild preeclampsia ,34 cases of severe preeclampsia) ,and forty-eight pregnant women with normal pregnancy in the same period were selected as control group .The serum level of A-FABP ,fasting insulin (FINS) ,placenta tissue level of A-FABP ,fasting blood glucose(FBG) were detected using enzyme linked im-munosorbent assay (ELISA ) ,immunohistochemistry and full automatic biochemical analyzer ,and homeostatic model assessment insulin resistance(HOMA-IR) was calculated .The relationship between the serum and pla-centa levels of A-FABP and HOMA-IR were contrastively analyzed .Results The serum and placenta levels of A-FABP ,FINS and HOMA-IR in preeclampsia group were significantly higher than those in the control group ,and the serum and placenta levels of A-FABP ,FINS and HOMA-IR in severe preeclampsia were also significantly higher than those in the mild preeclampsia (P<0 .05);The results of correlation analysis indicated that the placental level of A-FABP was positively correlated with the serum level of A-FABP(P<0 .01) ,and the serum and placentalevels of A-FABP were positively correlated with HOMA-IR in preeclampsia (P<0 .01) .Conclusion The levels of A-FABP and HOMA-IR increase in preeclampsia ,and the levels of A-FABP were positively correlated with HOMA-IR .The high levels of A-FABP increase insulin resistance ,indicating that this maybe involved in the pathogenesis of preeclampsia .关键词
脂肪细胞型脂肪酸结合蛋白/子痫前期/胰岛素抵抗Key words
adipocyte-fatty acid binding protein/preeclampsia/insulin resistance分类
医药卫生引用本文复制引用
李亚萍,邹余粮,张琳,黄新,秦勇..子痫前期患者A-FABP表达水平与胰岛素抵抗相关性研究[J].检验医学与临床,2018,15(1):12-15,4.基金项目
陕西省科学技术研究发展计划项目(2010K01-161). （2010K01-161）
