检验医学与临床2018，Vol.15Issue(1)：27-29,33,4.DOI:10.3969/j.issn.1672-9455.2018.01.008
某院下呼吸道流感嗜血杆菌耐药分析
Analysis of drug resistance of Haemophilus inf luenzae in lower respiratory of a hospital
摘要
Abstract
Objective To investigate the changes of the isolation and drug-resistance rates of Haemophilus inf luenzae isolated from 2013 to 2016 in a hospital and provide clinical reference for the treatment of lower re-spiratory infection(LRI) .Methods The datum of cases were collected and their specimens from lower respira-tory were cultured to isolate pathogen with chocolate agar for haemophilus (CAH) .Suspicious colonies were i-dentified with VITEK 2 compact system ,β-lactamase was detected by nitrocefin slips and the antibiotic sensi-tivity tests(AST) were done with ATB HAEMO card ,the results were interpreted according to CLSI M 100S-26 file .Results 27578 clinical data and samples were collected and 736 strains of Haemophilus influenzae were isolated .The detection rate was 2 .7％ (736/27578) and the rate was increasing year by year .Detection rate of children under the age of 7 was 4 .5％ (610/13656) ,it was high than adults(0 .3％ ,33/9551) and eld-ers(2 .1％ ,93/4371)(P<0 .05) .The positive rate of β-lactamase was 45 .7％ (336/736);The sensitive rates of the strains for ampicillin ,trimethoprim/sulfamethoxazole ,cefaclor and cefuroxime were all less than 50％w hile that for amoxicillin/clavulanic acid ,cefotaxime ,rifampicin ,ofloxacin ,chloramphenicol and tetracycline were all higher than 80％ .Conclusion The separation rate of Haemophilus inf luenzae is increasing year by year ,and the main susceptible population is children under 7 years old .The sensitivities of commonly used an-tibiotic are decreasing in different degree ,strains with β-lactamase remain stable .Amoxicillin/clavulanic acid can be empirical used for treatment of community acquired pneumonia (CAP) in children ,but this must be ad-justed according to the report of AST results .关键词
肺炎/流感嗜血杆菌/药物敏感试验Key words
pneumonia/Haemophilus inf luenzae/drug sensitivity test分类
医药卫生引用本文复制引用
王小龙,汪永强,袁平宗,张淑霞,黄作富,杨玉霖..某院下呼吸道流感嗜血杆菌耐药分析[J].检验医学与临床,2018,15(1):27-29,33,4.基金项目
国际医学研究基金(亚洲区)临床微生物学专项基金项目(CNSC-J2011-A3300). （亚洲区）
