老年医学与保健2017，Vol.23Issue(6)：542-545,4.
益气化聚方对早期糖尿病肾病大鼠尿微量白蛋白及细胞因子的影响
Effect of Yiqi Huaju Formula on Microalbuminuria and Cytokines in Rats with Early Type 2 Diabetic Nephropathy
摘要
Abstract
Objective To investigate the effect of Yiqi Huaju Formula on microalbuminuria and the expressions of nephrin and vascular endothelial growth factor receptor 2 (VEGFR2) in rats with early type 2 diabetic nephropathy.Methods Early diabetic nephropathy models were built up in rats with type 2 diabetes and then the rats were randomly divided into 4groups:control group,model group,Yiqi Huaju Formula group and Losartan group;after the administration of Yiqi Huaju Formula or Losartan for 8 weeks,fasting serum glucose,urinary microalbumin creatinine ratio (ACR) and 24h urinary albumin excretion rate (UAER) of the rats in each group were detected,and the histopathologic changes were observed;the expressions of nephrin,VEGFR2,Phospho-VEGFR2 (Tyr951) and Phospho-VEGFR2 (Tyr1175) in kidney tissues of the rats in the 4 groups were studied.Results The urinary microalbumin creatinine ratio (ACR),24h urinary microalbumin excretion rate (UAER) and the level of fasting serum glucose of the rats in Yiqi Huaju Formula group decreased much more than those of the rats in other groups (P＜0.01,P＜0.05 and P＜0.01),the glomerular basement membrane thickening and the exracellular matrix proliferation were more alleviated (P＜0.01,P＜0.05),and the expression of nephrin in kidney tissues was up-regulated while the expressions of VEGFR2,Phospho-VEGFR2 (Tyr951) and Phospho-VEGFR2 (Tyr1175) were down-regulated (P＜ 0.01).Conclusions Yiqi Huaju Formula can alleviate urinary microalbumin of the rats with early type 2 diabetic nephropathy,the mechanism may be related to the regulation of expressions of nephrin,VEGFR 2,p-VEGFR2 (Tyr951) and p-VEGFR2 (Tyr1175).关键词
糖尿病肾病/益气化聚方/尿微量白蛋白/肾病蛋白/血管内皮生长因子受体2Key words
diabetic nephropathy/Yiqi Huaju Formula/microalbuminuria/nephrin/vascular endothelial growth factor receptor 2 (VEGFR2)引用本文复制引用
张曾,何燕铭,王燕燕,郑敏,范朝华,张丹,杨宏杰,王文健..益气化聚方对早期糖尿病肾病大鼠尿微量白蛋白及细胞因子的影响[J].老年医学与保健,2017,23(6):542-545,4.基金项目
上海中医药大学预算内科研项目(2015YSN47) （2015YSN47）
