老年医学与保健2017，Vol.23Issue(6)：557-560,4.
老年慢性阻塞性肺疾病相关肺动脉高压患者血浆胃促生长素的变化特征与临床应用价值研究
Study on the Changes and Clinical Value of Plasma Ghrelin in the Elderly with Pulmonary Arterial Hypertension Related to Chronic Obstructive Pulmonary Disease
摘要
Abstract
Objective To explore the changes of plasma ghrelin in the elderly patients with pulmonary arterial hyper tension related to chronic obstructive pulmonary disease (COPD-PAH).Methods A retrospective analysis was made to the clinical data of 80 hospitalized patients with acute exacerbation of COPD,including 47 male and 33 female,aged from 65 to 79 years old with the average of 71.5;echocardiography before treatment showed all the patients with PASP ＞ 50 mmHg;the levels plasma ghrelin and IL-6 were detected,and arterial blood gas analysis,echocardiography and CAT questionnaire were performed in all the patients as well as the treatment of oxygen inhalation,anti-infection,spasmolysis,anti-asthma and phlegm expelling;10 days after treatment,the above index were detected again and the 80 patients were divided,according to the PASP values,into 2 groups:group A (n=32,PASP＞40 mmHg) and group B (n=48,PASP≤40 mmHg);a comparative study was made to the difference in plasma ghrelin,IL-6,pH value,PaO2,PaCO2,oxygenation index (PaO2/ FiO2) and CAT questionnaire scores between the 2 groups,the coefficients of plasma ghrelin and other index before and after treatment were calculated and correlative analysis was performed.Results Before treatment,there existed no statistical difference in plasma ghrelin,IL-6,pH value,PaO2,PaCO2,oxygenation index (PaO2/FiO2) and CAT questionnaire scores between the 2 groups (P＞0.05);the above index in group A were of no statistical difference before and after treatment(P＞0.05) while those in group B were of certain statistical dif ference before and after treatment (P ＜ 0.05);the plasma ghrelin concentrations of the patients in both groups before and after treatment were positively correlated to pH value,PaO2 and PaO2/FiO22 but negatively correlated to IL-6,PASP,PaCO2 and CAT questionnaire scores (P＜0.05).Conclusions Plasma ghrelin concentration is correlated to COPD-PAH in the elderly,which can provide reference for the diagnosis and treatment with certain clinical significance.关键词
老年/慢性阻塞性肺疾病/肺动脉高压/血浆/胃促生长素Key words
elderly/chronic obstructive pulmonary disease COPD)/pulmonary arterial hypertension (PAH)/plasm/ghrelin引用本文复制引用
张青,孙荣,丁薇,刘明,赵云峰,夏世金..老年慢性阻塞性肺疾病相关肺动脉高压患者血浆胃促生长素的变化特征与临床应用价值研究[J].老年医学与保健,2017,23(6):557-560,4.基金项目
上海市卫生和计划生育委员会面上课题(201640377) （201640377）
上海市浦东新区卫生系统重点专科培养计划资助(PWZzk2017-18) （PWZzk2017-18）
