南京医科大学学报（自然科学版）2017，Vol.37Issue(11)：1389-1394,6.DOI:10.7655/NYDXBNS20171103
FoxO3在复发胶质母细胞瘤中的表达及其对替莫唑胺耐药性的影响
Preliminary study on the expression of FoxO3 in recurrent glioblastoma and its resistance to chemotherapy
摘要
Abstract
Objective:To explore the expression level of tumor suppressor gene FoxO3 in the recurrent glioblastoma tissues and its potential function in temozolomide(TMZ) resistance.Methods:The expression level of FoxO3 mRNA and protein were detected and compared in primary and recurrent glioblastoma tissues via microarray,qPCT and Western blot.And then to explore the potential mechanism of FoxO3 mediated in TMZ resistance by screening its target using a microarray.Results:The expression level of FoxO3 mRNA and protein is decreased both in recurrent glioblastoma tissues and TMZ-resistance glioblastoma cell lines.Overexpression of FoxO3 could sensitize glioblastoma cells to TMZ via modulating the expression of REV3L.Conclusion:The expression level of FoxO3 is decreased in recurrent glioblastoma tissues,which might play a pivotal role in chemotherapy-resistance.Overexpression of FoxO3 could sensitize glioblastoma cells to TMZ via suppressing the expression of REV3L.关键词
胶质母细胞瘤/FoxO3/REV3L/替莫唑胺/耐药Key words
glioblastoma/FoxO3/REV3L/temozolomide/chemoresistance分类
医药卫生引用本文复制引用
胡大玲,张寅..FoxO3在复发胶质母细胞瘤中的表达及其对替莫唑胺耐药性的影响[J].南京医科大学学报（自然科学版）,2017,37(11):1389-1394,6.基金项目
国家自然科学基金(58201601) （58201601）
