实用肝脏病杂志2018，Vol.21Issue(1)：84-87,4.DOI:10.3969/j.issn.1672-5069.2018.01.020
超声引导下经皮微波消融治疗原发性肝癌患者疗效分析
Ultrasound-guided percutaneous microwave ablation and thymosin α-1 treatment in patients with primary liver cancer
摘要
Abstract
Objective To investigate the efficacy of ultrasound-guided percutaneous microwave ablation and thymosin α-1 treatment in patients with primary liver cancer (PLC). Methods A total of 104 patients with PLC were admitted to our hospital between March 2011 and March 2013 and they were randomly divided into observation group (n=52) and control group (n=52). The patients in control group were treated with ultrasound-guided percutaneous microwave ablation,and the ones in observation group were given subcutaneously with thymosin-α1. Results At the end of 4 week treatment,the CD3+ and CD4+ cells and the ratio of CD4+/CD8+were 71.49±6.57％,43.12±2.89％ and 15.89±3.24,significantly higher than 43.21±3.74％,24.56±2.36％ and 5.42± 2.13 in the control (P<0.05);the liver function index and serum alpha-fetoprotein levels in the observation group improved or decreased significantly than in the control (P<0.05);the complication occurrence in the observation group was 7.7％,not statistically significantly different with 11.5％ in the control (P>0.05);all patients were followed-up for 3 years,and the recurrence and metastasis in the observation group were 30.8％ and 15.4％,much lower than 50.0％ and 32.7％ in the control (P<0.05);the 3 a survival rate in the observation group was 23.1％(12/52),much higher than 5.8％ (3/52,P<0.05) in the control group. Conclusion Ultrasound-guided percutaneous microwave ablation followed by thymosin-α1 injection in the treatment of patients with PLC is efficient, with lower recurrence and metastasis and prolongation of survival,which warrants further investigation.关键词
原发性肝癌/经皮微波消融/胸腺素-α1/治疗/复发/转移Key words
Hepatoma/Percutaneous microwave ablation/Thymosin-α1/Efficacy/Recurrence引用本文复制引用
柏涛,龚凤云,胡旭东,王娟,夏冰,程海林,甘丽娟..超声引导下经皮微波消融治疗原发性肝癌患者疗效分析[J].实用肝脏病杂志,2018,21(1):84-87,4.基金项目
武汉市卫生与计划生育委员会科研课题 (编号:WX12D24) （编号:WX12D24）
