摘要
Abstract
Objective To investigate the levels of hepatic miRNA-155 in prognosis of patients with hepatocellular carcinoma (HCC). Methods Cancerous tissues in 50 patients with HCC and 50 normal liver tissue samples in our hospital between January 2013 and May 2014 were obtained. The miRNA levels in cancerous and liver tissues were detected by RT-PCR,and the relationship between miRNA-155 and prognosis was conducted. Results miRNA-155 in normal liver tissues (1.06 ±0.1) were lower than in HCC,and the miRNA-155 levels increased as HCC grading increased (P<0.05);the survival rate (24.00％) in patients with low hepatic miRNA-155 level was significantly higher than that in with high miRNA-155 level (9.24％,P<0.05);the survival in patients was significantly different between different HCC classification (14.26％ vs. 9.02％),tumor size (15.68％ vs. 10.02％),tumor metastasis (8.20％ vs. 14.46％),venous invasion (9.36％ vs. 14.36％),tumor differentiation (15.20％ vs. 7.84％) and different levels of miRNA-155(7.86％ vs. 16.32％,P<0.05);the tumor size (>5 cm,HR=1.46,P=0.038),tumor metastasis (HR=1.72,P=0.026),venous invasion (HR=1.46,P<0.001),tumor classification (HR=1.33,P=0.012) and miRNA-155 levels (HR=1.65,P<0.001) were the independent risk factors for poor prognosis (P<0.05) in patients with HCC. Conclusion miRNA-155 levels in liver cancer tissues is obviously higher than in normal liver tissues,and the high miRNA-155 levels is independent risk factor in patients with HCC.关键词
肝细胞癌/miRNA-155/预后Key words
Hepatocellular carcinoma/miRNA-155/Prognosis
