现代妇产科进展2018，Vol.27Issue(1)：18-22,5.DOI:10.13283/j.cnki.xdfckjz.2018.01.005
放化疗治疗Ⅱb～Ⅳa期局部晚期宫颈癌有效性与安全性的meta分析
Efficacy and safety of chemoradiotherapy for stages Ⅱb～Ⅳa locally advanced cervix cancer:a Meta-analysis
摘要
Abstract
Objective:To systematically review the efficacy and safety of chemoradio-therapy for LACC(stage Ⅱb～Ⅳa). Methods:We searched The Cochrane Library,PubMed, Embase,Web of science,CBM,VIP,CNKI,and WanFang Data,from their established dates to July 2017. According to the inclusion and exclusion criteria,the eligible randomized controlled trials (RCTs) were selected. After we extracted data and assessed the quality,Meta-analysis was performed by using RevMan 5. 3 sofware. Result:A total of 15 randomized controlled trials were included. The results of meta-analysis showed that,compared with the radiotherapy alone, chemoradiotherapy had significantly increased complete response rates ( OR=2. 20,95％CI=1. 66～2. 92,P<0. 00001),5-year disease-free survival rates(OR=1. 84,95％CI=1. 39 ～2. 42,P<0. 0001),3-year survival rates(OR=1. 76,95％CI=1. 43 ～2. 16,P<0. 00001),5-year survival rates(OR=1. 74,95％CI=1. 37～2. 21,P<0. 00001). However,chemoradiother-apy has a higher incidence of grade Ⅲ/Ⅳ acute toxicities(OR=3. 41,95％CI=2. 29～5. 09,P<0 . 00001 ) .Ⅲ/Ⅳ level late toxicities ( OR=1 . 36 ,95％CI=0 . 87 ～2 . 13 , P=0 . 18 ) in both groups were equivalent. Conclusion:Chemoradiotherapy improves long-term and short-term cur-ative effects for patients with locally advanced cervix cancer,and has higher incidence of grade Ⅲ/Ⅳa acute toxicities. However,due to the limited quantity and quality of the included studies, more high quality studies with large sample size are still needed to verify the above conclusion.关键词
宫颈癌/放化疗/放疗/meta分析Key words
Cervix cancer/Chemoradiotherapy/Radiotherapy/Meta-analysis分类
医药卫生引用本文复制引用
安慧蒙,郑荣芳,梁盼盼,王龙,范维,郭钰珍..放化疗治疗Ⅱb～Ⅳa期局部晚期宫颈癌有效性与安全性的meta分析[J].现代妇产科进展,2018,27(1):18-22,5.基金项目
甘肃省自然科学基金(No:2017GS10980) （No:2017GS10980）
