现代妇产科进展2018，Vol.27Issue(1)：28-32,5.DOI:10.13283/j.cnki.xdfckjz.2018.01.007
不同手术方式治疗宫颈上皮内瘤变的近、远期疗效分析
Clinic research of short-term and long-term efficacy after therapy for cervical intraepi-thelial neoplasia
摘要
Abstract
Objective:To evaluate the short-term and long-term efficacy after therapy for cervical intraepithelial neoplasia( CIN) and prevent CIN progression,and explore the influ-encing factors of recurrence. Methods:A multi-center retrospective study of 1226 cases about high grade intraepithelial neoplasia between 2009 and 2014 was involved from 3 third-grade class-A communal hospitals in Guangxi Province. The clinical efficacy of surgical cone,patho-logic positive margins,and postoperative recurrence were assessed with univariate and multivari-ate analysis. Results:There was significant difference in estimated blood loss and intra-operative time between CKC group and LEEP group. There was no significant difference in surgical mar-gins in the two groups. Univariate analysis showed that age,menopause,the range of lesions,col-poscopy whether satisfaction may be related to risk factors as affecting surgical margin status ( P<0. 05). Logistic regression analysis revealed that menopause,the range of lesions,colposcopy whether satisfaction were risk factors of postoperative positive margin. Cox regression analysis showed that margin status,persistent infection of high-risk HPV and menopause were risk fac-tors for recurrence after surgical cone. Conclusions:Both CKC and LEEP are safe and effective methods for CIN treatment and prohibition of CIN progress. Positive margin,high-risk HPV per-sistent infection and menopause are risk factors for CIN recurrence. Repeat conization may be choosen for positive margins.关键词
宫颈上皮内瘤变/冷刀锥切术/宫颈环形电切术/人乳头瘤病毒/切缘/复发Key words
Cervical intraepithelial neoplasia/Human papillomavirus/Cold knife conization/Loop electrosurgical excision procedure/Reccurrence/Surgical margin分类
医药卫生引用本文复制引用
蒋燕明,王鹤,贺红英,李力..不同手术方式治疗宫颈上皮内瘤变的近、远期疗效分析[J].现代妇产科进展,2018,27(1):28-32,5.基金项目
国家卫计委公益性行业科研专项(No:201402010) （No:201402010）
