摘要
Abstract
Objective:To evaluate the colonization of group B streptococcus of late-pregnant women in Chengdu and the perinatal outcome after antibiotics usage. Methods:538 pregnant women between 35 to 37 weeks,who underwent routine pregnant examination in our hospital from Jan. 2015 to Mar. 2017 were included in our research. Specimen was taken from each patient's vagina and rectum using standard methods. According to the culture result,the pregnant women were divided into GBS positive group and GBS negative group. Antibiotics were given to prevent infection for GBS positive group during labor,and the perinatal outcomes of the two group were compared. Result:(1)A total of 1076 samples were collected from 538 pregnant women. The positive rate was 5. 11％. 538 pregnant women in this study,vaginal and rectal se-cretions joint examination positive rate was 7 . 62％( 41/538 ) , vaginal secretion samples were 5. 58％(30/538),and rectal secretion samples were 4. 65％(25/538). Compared with com-bined screening and individual screening for rectal specimens GBS colonization,there was a sta-tistically significant difference. However,compared with individual screening for vaginal speci-mens,as well as the rectal specimens compared with the rate of vaginal specimens separately,no significant difference was observed. (2)Among the 538 pregnant women,33 families which one of the couple worked on health care,the GBS colonization rate was 18. 18％(6/33),while in families of other profession,the GBS colonization rates was 6. 93％(35/505). There was a sta-tistically significant difference. (3)In GBS-positive group,29 pregnant women who selected va-ginal trail-delivery were given antibiotic therapy in labor. Specimen was taken from each neo-natal's nose and ear for GBS culture,the positive rate was 6. 90％(2/29). (4) There was no significant differences in perinatal outcomes such as preterm labor,premature rupture,meconi-um-stained amniotic fluid, fetal distress, postpartum hemorrhage, neonatal birthweight, Apgar score,neonatal pneumonia and neonatal transfer NICU rates between GBS-positive group and negative group. Conclusion:The colonization rate of GBS in the third trimester pregnancy in Chengdu is 7. 62％. When one of the couple is occupied in health care,the colonization rate is significantly up to 18 . 18％. Combined screening of vagina and rectum can improve the GBS de-tection rate. Prophylactic use of antibiotics in GBS positive pregnant women does not increase the incidence of adverse perinatal outcomes. Therefore, attention should be paid to standard screening of GBS in pregnant women in late pregnancy,especially who has high-risk pregnant factors,then carrying out standardized prevention intervention to effectively improve perinatal outcomes.关键词
B群链球菌/定植/预防/围产结局Key words
Group B streptococcus/Colonization/Prevention/Perinatal outcome分类
医药卫生
