畜牧兽医学报2017，Vol.48Issue(12)：2232-2238,7.DOI:10.11843/j.issn.0366-6964.2017.12.002
磷酸酶Wip1基因敲除表型及机制研究进展
Research Progress of Wip1 Phosphatase Knockout Phenotypes and Underlying Mechanisms
摘要
Abstract
Wip1 (Wild-type p53-induced phosphatase1) is a member of PP2C (The type 2C family of protein phosphatases) family of phosphatases,which plays important roles in DNA damage repair and has attracted increasing attention as a oncogene.Wip1 knockout mice were viable,but exhibited reduced longevity,along with multiple-system abnormalities,including reproductive system,immune system,endocrine system and nervous system.The detailed phenotypes included male reproductive organ atrophy,male infertility,increased susceptibility to pathogens,diminished T-and B-cell function,insulin resistance,impaired body weight,declined fat mass,elevated anxiety-and depression-like behaviors and so on.The studies for the underlying molecular mechanisms further demonstrated that Wip 1 played critical roles in a variety of physiological and pathological processes through dephosphorylating different substrate proteins.Therefore,in this review,we comprehensively discussed the phenotypes caused by Wip 1 knockout in mouse as well as the possible underlying molecular mechanisms,which may provide information for further understanding the biological function of Wip 1,and the possible mechanisms underlying the physiological and pathological processes in mammals.关键词
Wip1敲除/小鼠/多系统异常/分子机制Key words
Wip 1 knockout/mouse/multiple-system abnormalities/molecular mechanisms分类
生物科学引用本文复制引用
王冰源,刘志国,牟玉莲..磷酸酶Wip1基因敲除表型及机制研究进展[J].畜牧兽医学报,2017,48(12):2232-2238,7.基金项目
国家自然科学基金(31572378) （31572378）
农业部中央级公益性科研院所基本科研业务费项目(2016ywf-yb-4) （2016ywf-yb-4）
