畜牧兽医学报2017，Vol.48Issue(12)：2249-2257,9.DOI:10.11843/j.issn.0366-6964.2017.12.004
禽源呼肠孤病毒诱导宿主免疫应答研究进展
The Research Advance of Host Immune Response Induced by Avian-origin Reovirus
摘要
Abstract
Avian-origin reovirus,which is a kind of important poultry and waterfowl pathogen,can cause serious damage to the bursa of Fabricius,spleen and thymus of infected birds,resulting in immunosuppression and increased susceptibility to secondary diseases that greatly hinder the healthy development of global poultry and waterfowl industry.The innate immune response is the hotspot in the field of microbiology and immunology due to its earlier and quick non-specific response against pathogens.Adaptive immune response can eliminate the intruding pathogens,and defend against reinfection of the same pathogens,which provides immunological basis for the immunization of host.In this review,we highlight the current understanding of host innate immune response and adaptive immune response induced by avian-origin reovirus and the effects of such virus infection on the host immune system.This review will provide a basis for understanding the virus-host interaction and vaccine development.关键词
禽源呼肠孤病毒/天然免疫应答/适应性免疫应答/免疫抑制Key words
avian-origin reovirus/innate immunity/adaptive immunity/immunosuppression分类
农业科技引用本文复制引用
池晓娟,邵文涵,陈吉龙,陈月香,王松..禽源呼肠孤病毒诱导宿主免疫应答研究进展[J].畜牧兽医学报,2017,48(12):2249-2257,9.基金项目
国家自然科学基金(31402217 （）
U1305212) （）
福建省教育厅资助省属高校专项课题(JK2015011) （JK2015011）
