中国实用外科杂志2017，Vol.37Issue(12)：1397-1401,1412,6.DOI:10.19538/j.cjps.issn1005-2208.2017.12.20
前哨淋巴结阳性Luminal B型早期乳腺癌非前哨腋窝淋巴结状态对预后影响研究
Effect of non-sentinel lymph node status on prognosis of Luminal B (HER2 negative) early breast cancer with positive sentinel lymph nodes
摘要
Abstract
Objective To evaluate the effect of non-sentinel lymph node status on prognosis of Luminal B (HER2 negative) early breast cancer.Methods Luminal B (HER2 negative) early breast cancer with positive sentinel lymph node treated from January 2008 to December 2014 in Peking University First Hospital entered the retrospective study.The clinicopathological features and their relationship with non-sentinel lymph nodes status were analyzed statistically.The effect of non-sentinel lymph nodes status on prognosis of Luminal B (HER2 negative) early breast cancer with positive sentinel lymph nodes were also analyzed.Results In the group of 142 patients with positive sentinel lymph nodes (SLN),the average number of SLNs detected in each patient were 2.06± 1.26.The number of positive SLNs was associated with the status of non-sentinel lymph nodes,but not the age,BMI,menopause,T stage,histological grade,lympho-vascular invasion.Non-SLN axillary lymph node non-metastasis occurred in 78 patients (54.9％),DFS 93％,OS 93.1％;non-SLN axillary lymph node metastasisoccurred in 64 patients (45.1％),DFS 95.2％,OS 91.9％.Based on Log-rank (Mantel-Cox) test,There was no significant difference between two groups in DFS (x 2=0.011,P=0.918) and OS (x 2=0.348,P=0.555).Conclusion The number of positive sentinel lymph nodes in Luminal B (HER2 negative) early breast cancer patients with sentinel lymph nodes metastasis were associated with the status of non-sentinel lymph nodes.There were no statistical differences between non-sentinel lymph nodes metastasis group and non-metastasis group in disease free survival and over-roll survival.关键词
乳腺癌/Luminal B型/前哨淋巴结活检/非前哨腋窝淋巴结Key words
breast cancer/Luminal B (HER2 negative)/sentinel lymph node biopsy/non-sentinel lymph node分类
医药卫生引用本文复制引用
叶京明,刘荫华,徐玲,刘倩,程元甲,辛灵,段学宁,张虹,张爽,李挺..前哨淋巴结阳性Luminal B型早期乳腺癌非前哨腋窝淋巴结状态对预后影响研究[J].中国实用外科杂志,2017,37(12):1397-1401,1412,6.基金项目
国家重点研发计划精准医学研究重点项目“乳腺癌专病队列研究”乳腺癌多中心临床队列研究(No.2016YFC0901302) （No.2016YFC0901302）
北京市科委科技计划重大项目(No.D090507043409010) （No.D090507043409010）
首都医学发展科研基金项目(No.2009-1011) （No.2009-1011）
首都临床特色应用研究(No.Z131107002213007) （No.Z131107002213007）
