中国现代医学杂志2017，Vol.27Issue(30)：36-40,5.DOI:10.3969/j.issn.1005-8982.2017.30.006
s671和rs1801157基因多态性与云南汉族人群心肌梗死的易感性分析
Correlation analysis of rs671 and rs1801157 polymorphisms and myocardial infarction in Han population of Yunnan province
摘要
Abstract
Objective To investigate the potential correlation of single nucleotide polymorphism (SNP) of rs671 as well as rs1801157 and myocardial infarction(MI) in a group of Chinese Han population from Yunnan province.Methods Sequenom MassArray system genotyping was utilized to identify the polymorphisms of rs671 and rs1801157 in 500 MI patients as well as 350 healthy volunteers.The potential association between MI and SNPs was analyzed in addition to consideration of major independent risk factors such as gender,age,hypertension,diabetes,lipid concentration,obesity,smoking,drinking and family history.Results Genotypes of rs671 and rs1801157 were equally distributed in MI group and control group.Frequency of AA,A and AG genotype in rs671 of MI group was higher while GG genotype was lower significantly than that in control group (P＜ 0.05).Frequency of GG,GA and G genotype in rs1801157 of MI group was higher while AA and A genotype was significantly lower than that in control group (P＜ 0.05).In additive model,A allele of rs671 and G allele of rs1801157 increased risk of MI with OR equal to 2.57 (95％ CI:1.96,3.37,P＜0.05).In dominant model,A allele of rs671 increased risk of MI with CR equal to 3.69 (95％ CI:2.68,5.08,P ＜0.05).In recessive model,no significant correlation between rs671 as well as rs1801157 and MI was observed with OR equal to 3.86 (95％ CI:0.88,17.03,P=0.074).A allele of rs671 increased risk of MI in nondrinking patients with OR equal to 1.27 (95％ CI:1.05,2.93,P =0.032),while no such association was observed in drinking patients with OR equal to 1.58 (95％ CI:0.84,1.87,P =0.36).No correlation was founded between drinking and rs1801157 polymorphism as MI risk factors.Conclusions Polymorphic variation of rs671 and rs1801157 is closely associated with susceptibility to MI in Chinese Han population of Yunnan province.Alleles of rs671 and rs1801157 are genetic risk factors of MI.关键词
心肌梗死/rs671/基因多态性/遗传易感性Key words
myocardial infarction/rs671/gene polymorphism/susceptibility分类
医药卫生引用本文复制引用
刘萍,光雪峰,张富荣,何亮,杨麦巧,王芳..s671和rs1801157基因多态性与云南汉族人群心肌梗死的易感性分析[J].中国现代医学杂志,2017,27(30):36-40,5.基金项目
云南省应用基础研究计划(昆医联合专项)(No:2013FZ288) （昆医联合专项）
