中国现代医学杂志2017，Vol.27Issue(30)：41-45,5.DOI:10.3969/j.issn.1005-8982.2017.30.007
IQ结构域GTP酶激活蛋白1在胰腺癌中表达及与预后的相关性研究
Expression and prognostic role of IQGAP1 in patients with pancreatic adenocarcinoma
摘要
Abstract
Objective To investigate expression the level of IQ-domain GTPase-activating protein 1 (IQGAP1) and its prognostic significance in pancreatic adenocarcinoma.Methods A total of 66 cases of patients diagnosed with pancreatic adenocarcinoma were included in this study.A total of 66 cancer samples as well as 49 paracancerous normal tissues were harvested,and the expression level of IQGAP1 was measured by Immunohistochemistry.The correlation analysis of IQGAP1 expression and clinical manifestations were performed.Results IQGAP1 was upregulated significantly in cancer tissue when compared with normal tissue (63.636％ vs 12.245％,P＜ 0.05).Expression of IQGAP1 was closely associated with clinical features including histological grading and lymph node metastasis (P ＜ 0.05).No significant correlation was observed between IQGAP1 and age,gender,size or position of tumor,neural invasion or clinical stage of patients (P ＞0.05).Patients with positive expression of IQGAP1 experienced shorter overall survival time as compared with those without IQGAP1 expression (P =0.002).Multivariate Cox regression analysis demonstrated that IQGAP1 overexpression was an independent prognostic factor in pancreatic adenocarcinoma (HR =2.128,95％ CI =1.127,4.019,P=0.020).Conclusions Up-regulation of IQGAP1 may be involved in tumor progression,and is potentially a prognostic biomarker.关键词
IQ结构域GTP酶激活蛋白1/胰腺癌/免疫组织化学/生存分析Key words
IQ-domain GTPase-activating protein 1/pancreatic ductal adenocarcinoma/Immunohistochemistry/prognosis分类
医药卫生引用本文复制引用
胡伟,王磊,孙磊,高泰龙..IQ结构域GTP酶激活蛋白1在胰腺癌中表达及与预后的相关性研究[J].中国现代医学杂志,2017,27(30):41-45,5.基金项目
连云港市第一人民医院青年英才豪森基金资助项目(No:QN150102) （No:QN150102）
连云港市科技局项目(No:SH1218) （No:SH1218）
