中国现代医学杂志2017，Vol.27Issue(30)：46-50,5.DOI:10.3969/j.issn.1005-8982.2017.30.008
端粒锌指相关蛋白在乳腺癌中的表达及其临床病理意义
Expression of telomeric protein ZBTB48 in breast cancer and clinical significance
傅椰 1何潇2
作者信息
- 1. 南华大学附属第一医院普通外科,湖南衡阳421001
- 2. 湖南省肿瘤医院乳腺外科,湖南长沙410006
- 折叠
摘要
Abstract
Objective To investigate the expression of telomeric zinc finger-associated protein (ZBTB48) in breast cancer and its clinical significance.Methods A total of 90 cases of patients diagnosed with breast cancer were included in this study.Cancer tissue as well as paracancerous normal tissue was collected for further analysis.RT-PCR and Immunohistochemistry were utilized to measure expression levels of ZBTB48 and Ki-67.Correlation between ZBTB48 expression in cancer tissue and patients' clinical manifestation was analyzed under network public database.Results RT-PCR and Immunohistochemistry data suggested that expression levels of ZBTB48 in cancer tissue were significantly decreased compared with normal tissue (P1 =0.0289;P2 =0.000).The expression level of Ki-67 protein was negatively correlated with ZBTB48 (P =0.0005).Concentration of ZBTB48 was closely correlated with age,size as well as differentiation of tumor and TNM stage.Overall data indicated that patients with low expression of ZBTB48 were more likely to experience poor outcome.Conclusions ZBTB48 in breast cancer tissue is closely associated with age,size and differentiation of tumor,and TNM stage of breast cancer;low expression of ZBTB48 is a risk factor of breast cancer.关键词
端粒锌指相关蛋白/端粒/乳腺癌/临床病理/预后Key words
zinc finger and BTB domain 48/telomere/breast cancer/clinicopathological factor/prognosis分类
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傅椰,何潇..端粒锌指相关蛋白在乳腺癌中的表达及其临床病理意义[J].中国现代医学杂志,2017,27(30):46-50,5.
