中国现代医学杂志2017，Vol.27Issue(30)：88-92,5.DOI:10.3969/j.issn.1005-8982.2017.30.016
右美托咪定对烧伤脓毒症患者TNF-α、NF-KB、IL-6及血气分析指标的影响
Effect of Dexmedetomidine on TNF-α, NF-κB, IL-6 and blood gas analysis index of burn patients with sepsis
摘要
Abstract
Objective To explore the effect of Dexmedetomidine on TNF-α,nf-kappa B (NF-κB),IL-6 and blood gas analysis index of bum patients with sepsis.Methods A total of 50 burn patients with sepsis receiving selective operation were selected from January 2015 to March 2017.They were divided into observation group and control group according to random number table,each group included 25 cases.All the patients received general anesthesia induction,the observation group was given Dexmedetomidine 0.3 μg/kg by intravenous infusion 15 min before anesthesia induction,and 0.3 μg/(kg·h) by intravenous infusion during the operation.The control group was given normal saline at the same dosage.Blood pressure,heart rate (HR),arterial blood gas analysis index,the level of TNF-α,NF-κB and IL-6 in venous blood,hospital stay and 28-day fatality rate were compared between the two groups at different time points.Results The MAP and HR at T1,T2,T3 and T4 were no difference between two groups (P＞ 0.05).the levels of TNF-α,NF-κB,IL-6 at different time points were significantly different (F=13.322,5.362 and 21.457;P=0.000,0.034 and 0.000),the levels of TNF-α,NF-κB,IL-6 were different between two groups (F=11.472,16.813 and 14.195;all P=0.000),the levels of TNF-α,NF-κB,IL-6 observation group were lower than the control group.the change trends of TNF-α,NF-κB,IL-6 were significantly different (F=14.623,4.974 and 19.765;P=0.000,0.038 and 0.000).the levels of PaO2,PaCO2/FiO2 at different time points were different (F=15.382,17.367;all P=0.000).The levels of PaO2,PaCO2/FiO2 were significantly different between two groups (F=9.276,12.343;all P=0.000),the observation group were higher than the control group,the change trends of PaO2,PaCO2/FiO2 levels in two groups were significantly different (F=9.156,10.485;all P=0.000).The hospital stay in the observation group (8.3 ± 1.4) d was significantly lower than the control group (9.3 ± 1.5) d (P ＜ 0.05).Conclusions Dexmedetomidine improves the balance of hemodynamics during the operation in burn patients with sepsis,acting an effective protection to lung tissue,which is worthy of clinical popularization and application.关键词
烧伤脓毒症/右美托咪定/炎症因子/肺功能/血气分析Key words
burn sepsis/Dexmedetomidine/inflammation factors/lung function/blood gas analysis分类
医药卫生引用本文复制引用
张彩玲,肖光文,肖谊民,宋琳苑,廖婷..右美托咪定对烧伤脓毒症患者TNF-α、NF-KB、IL-6及血气分析指标的影响[J].中国现代医学杂志,2017,27(30):88-92,5.基金项目
广东省梅州市科学技术局审批项目(No:2016B041) （No:2016B041）
