中国畜牧兽医2017，Vol.44Issue(12)：3670-3675,6.DOI:10.16431/j.cnki.1671-7236.2017.12.039
地塞米松对仔猪肠道黏膜形态的影响
Effect of Dexamethasone on Mucosa Morphology in Piglets
摘要
Abstract
This study was aimed to investigate the effects of dexamethasone on the morphology of intestinal mucosa and intestinal immune barrier function,and study the feasibility of setting up the piglets intestinal damage model,which could provide a theoretical and scientific basis for the future research of the mechanism and prevention measures caused by other intestinal injury of glucocorticoids.30 healthy piglets (1 week after weaning) were randomly divided into 6 groups,with 5 replicates in each group.The experimental groups Ⅰ,Ⅱ and Ⅲ were injected with dexamethasone 1,2 and 3 mL,the control groups Ⅰ,Ⅱ and Ⅲ were injected with saline 1,2 and 3 mL,respectively.HE staining,PASstainingand ELISA detection method were used to measure the intestinal villus length and crypt depth,villus length and crypt depth ratio,goblet cells and intraepithelial lymphocytes and sIgA.The results were as follows:Dexamethasone inhibited the growth of intestinal villus,the crypt depth became deeper,villus length and crypt depth ratio decreased,and the number of goblet cells,intraepithelial lymphocytes and sIgA levels were reduced in experimental groups,and the greater the dose,the more obvious the indicators changed.It suggested that dexamethasone could affect the growth of intestinal villus and the intestinal absorption of nutrients,damage mucosal immune barrier function in a dose dependent.关键词
地塞米松/仔猪/肠道黏膜/形态Key words
dexamethason/piglets/intestinal mucosa/morphologye分类
农业科技引用本文复制引用
潘书磊,邓红玉,阮国荣,王全溪..地塞米松对仔猪肠道黏膜形态的影响[J].中国畜牧兽医,2017,44(12):3670-3675,6.基金项目
福建省教育厅B类科技项目(JB12377) （JB12377）
福建农业职业技术学院院级课题(11-ZM-02) （11-ZM-02）
福建省生猪产业体系建设项目(闽财指(2015)0640) （闽财指(2015）
