中国医学前沿杂志（电子版）2017，Vol.9Issue(9)：96-100,5.DOI:10.12037/YXQY.2017.09-23
老年人血浆同型半胱氨酸水平和颈动脉粥样硬化关系的研究
Study of relation between elevated homocysteine and carotid atherosclerosis in elderly people
摘要
Abstract
Objective To explore the relation between plasma homocysteine (Hcy) and carotid athero-sclerosis in elderly people. Method 766 elderly people who took physical examination in Beijing Jiaotong University Community Health Center from January 2015 to June 2015 were prospectively investigated in this study, they were divided into normal group (n=555) and elevated group (n=211) according to their levels of plasma Hcy. Carotid artery ultrasounds were performed. Result The mean total plasma Hcy was statistically higher in elevated group than normal group [(20.38±6.92) μmol/L ： (11.40±2.02) μmol/L, P=0.000].Carotid plaques were detected in 578 individuals and stenosis were found in 47 individuals.The prevalence of intima-media thickness (IMT) increase and bilateral plaques in elevated group were significantly higher than those of normal group (59.7%：50.3%, P=0.019; 53.6%： 44.7%, P=0.040). The frequency of IMT-increase and carotid stenosis were higher in males than females (63.9%：41.3%, P=0.000; 8.7%：3.5%, P=0.003). Conclusion Carotid plaques are widely detected in elderly people. Carotid atherosclerosis is more serious with increasing Hcy levels. Worse condition of carotid atherosclerosis is found in male.关键词
老年/同型半胱氨酸/颈动脉/动脉粥样硬化Key words
Geriatrics/Homocysteine/Carotid arteries/Atherosclerosis引用本文复制引用
聂颖,冯新恒,陈宝霞,邱文风,夏蓉晖,卢云涛,庄润涛..老年人血浆同型半胱氨酸水平和颈动脉粥样硬化关系的研究[J].中国医学前沿杂志（电子版）,2017,9(9):96-100,5.基金项目
北京交通大学基本科研基金自由申报项目(016JB00040) （016JB00040）
