中国医院用药评价与分析2017，Vol.17Issue(12)：1614-1615,1618,3.DOI:10.14009/j.issn.1672-2124.2017.12.008
孟鲁司特钠口服联合布地奈德雾化吸入对咳嗽变异性哮喘患者肺功能及相关血清免疫指标水平的影响
Effects of Montelukast Sodium for Oral Combined with Budesonide for Aerosol Inhalation on Pulmonary Function and Serum Immune Indices of Patients with Cough Variant Asthma
郑雪玲 1李文波 1郝建伟2
作者信息
- 1. 焦作市中医院检验科,河南焦作 454000
- 2. 焦作市中医院内科,河南焦作454000
- 折叠
摘要
Abstract
OBJECTIVE: To probe into the effects of montelukast sodium combined with budesonide for aerosol inhalation on pulmonary function and serum Immune indices of patients with cough variant asthma .METHODS: 78 patients with cough variant asthma admitted into Jiaozuo Traditional Chinese Medicine Hospital during 2016-2017 were selected and numbered to be 1-78, patients with odd numbers were classified as observation group , even numbers were control group , with 39 cases in each group .The control group was treated with budesonide aerosol for inhalation , while the observation group was given montelukast sodium combined with budesonide aerosol .After an 8-week treatment , two groups were compared before and after treatment in terms of pulmonary function [ ( forced expiratory volume in first second (FEV1) and forced vital capacity (FVC)] and serum Immune indices including serum immune globulin E (IgE), tumor necrosis factor α(TNF-α) and interleukin 4 (IL-4), the incidences of adverse drug reactions of two groups were observed .RESULTS: After treatment, the FEV1 and FVC levels of both groups had been significantly increased , and those of the observation group were significantly higher than the control group , with statistically significant differences (P<0.05);after treatment, the IgE, IL-4 and TNF-αlevels of both groups had been significantly increased , and those of the observation group were significantly higher than the control group , with statistically significant differences (P<0.05).There was no statistical significance in the difference of incidences of adverse drug reactions between two groups ( P >0.05 ) . CONCLUSIONS: The efficacy of montelukast sodium combined with budesonide for aerosol inhalation in treatment of cough variant asthma is remarkable , which can improve patients ' pulmonary function and relieve inflammation reactions , with high safety .关键词
咳嗽变异性哮喘/布地奈德气雾剂/孟鲁司特钠/肺功能Key words
Cough variant asthma/Budesonide aerosol/Montelukast sodium/Pulmonary function分类
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郑雪玲,李文波,郝建伟..孟鲁司特钠口服联合布地奈德雾化吸入对咳嗽变异性哮喘患者肺功能及相关血清免疫指标水平的影响[J].中国医院用药评价与分析,2017,17(12):1614-1615,1618,3.
