中国医院用药评价与分析2017，Vol.17Issue(12)：1692-1695,1698,5.DOI:10.14009/j.issn.1672-2124.2017.12.037
2012—2016年益阳市中心医院大肠埃希菌耐药性变迁及其与抗菌药物用药频度、使用强度的相关性分析
Analysis on Drug-resistance Evolution of Escherichia Coli.and Correlation with Defined Daily Dose System and Antibiotics Use Density of Antibiotics in Yiyang Central Hospital During 2012-2016
摘要
Abstract
OBJECTIVE:To understand the drug-resistance evolution of Escherichia coli( E.coli) and correlation with defined daily dose system ( DDDs) and antibiotics use density ( AUD) of antibiotics in Yiyang Central Hospital ( Hereinafter referred to as "the hospital") during 2012-2016 , so as to provide reference for the rational drug application in clinic .METHODS:Retrospective analysis was conducted on the changes of drug resistance rate of E. coli and the situation of DDDs and AUD in the same period during 2012-2016 , and the correlation between drug resistance rate and DDDs and AUD were analyzed .RESULTS:During 2012-2016, the annual inspection of E.coli in the rate were 18.13％(874/4822 strain) , 20.78％(1183/5692 strain) , 20.41％(947/4639 strain) , 23.88％(752/3149 strain) and 22.96％(750/3266 strain), and which were in an increasing tendency .The detection rate of ESBL <57.5％.The E.coli to ampicillin and cefazolin showed higher resistance rate , and to levofloxacin , ceftazidime showed relatively high resistance rate , yet the overall data showed a downward trend year by year .During 2012-2016, the DDDs of levofloxacin, cefoperazone sulbactam and piperacillin tazobactam dominated the top 3 places, the r were respectively -0.129, -0.609 and -0.709.The AUD of levofloxacin, cefoperazone sulbactam and piperacillin tazobactam were relatively high , the r were respectively 0.329, -0.282 and -0.600.CONCLUSIONS:The tendency of antibiotic resistance in E.coli of the hospital has been checked , the application of antibiotics become more standard .It is necessary to strengthen the intervention on the whole application of antibiotics , so as to achieve the maximum efficiency , delay the development of bacterial resistance , and promote the rational application of drugs .关键词
大肠埃希菌/细菌耐药率/抗菌药物/用药频度/使用强度Key words
E.coli/Bacterial drug resistance rate/Antibiotics/DDDs/AUD分类
医药卫生引用本文复制引用
刘英,姚志红,肖晶,詹煦旭,刘阳,任志强..2012—2016年益阳市中心医院大肠埃希菌耐药性变迁及其与抗菌药物用药频度、使用强度的相关性分析[J].中国医院用药评价与分析,2017,17(12):1692-1695,1698,5.基金项目
湖南省卫生厅科研计划课题(No.B2013-150) （No.B2013-150）
