中成药2017，Vol.39Issue(12)：2491-2496,6.DOI:10.3969/j.issn.1001-1528.2017.12.009
滋阴补阳序贯治疗联合促排卵对PCOS不孕症患者子宫内膜HOXA10的调控
Sequential therapy combined with ovulation induction of PCOS in endometrium of infertile women
摘要
Abstract
AIM To observe the endometrium receptivity of polycystic ovary syndrome patients and research advance of expression of HOXA10 in endometrium.METHODS Eighty PCOS patients were divided into treatment group and control group,40 persons in each group randomly.The control group was treated with clomiphene (CC) + human menopausal gonadotropin (HMG) + human chorionic gonadotropin (HCG),and the treatment group was treated with CC + HMG + HCG + Yin-Nourishing Yang-Supplementing.After 3 periods,take a record for below:endometrial thickness (Em) in the middle,advanced stage and mid-secretory phase of hyperplasia endometrii,the levels of spiral artery PI/RI in midluteum endometrium,the levels in serum of E2 and P in midluteum endometrium,the expression of HOXA10 mRNA from both groups,clinical pregnancy rate and abortion rate for each group.RESULTS Compared with the control group,endometrial thickness in the treatment group was increased and there is statistical difference in the middle and late follicle phases (P ＜ 0.05),but there was no statistical difference in midluteum endometrium (P ＞ 0.05);the level of E2 and P in the treatment group were raised (P ＜0.05) with statistical significance;PI and RI were obviously contracted (P ＜ 0.01).Expression of HOXA10 mRNA was increased (P ＜ 0.01).Compared with the control group,the treatment group had a significant difference in pregnancy rate (P ＜ 0.05).The abortion rate was lower,but there was no statistical significance (P ＞ 0.05).CONCLUSION Yin-Nourishing Yang-Supplementing Treatment can obtain higher pregnancy rate and lower abortion rate of PCOS patients and the mechanism might be associated with raising the expression of HOXA10 mRNA and reducing spiral artery PI/RI,also improving the function of corpus luteum treatment,then to improve the receptivity of endometrium.Yin-Nourishing Yang-Supplementing Treatment is well worth popularizing in further clinical application.关键词
多囊卵巢综合征/滋阴补阳序贯/子宫内膜容受性/HOXA10Key words
polycystic ovary syndrome/sequential Yin-nourishing Yang-supplementing/endometrium receptivity/HOXA10分类
医药卫生引用本文复制引用
童星丽,谈勇,殷燕云,周阁..滋阴补阳序贯治疗联合促排卵对PCOS不孕症患者子宫内膜HOXA10的调控[J].中成药,2017,39(12):2491-2496,6.基金项目
江苏省科技厅临床医学科技专项(SBL201320056) （SBL201320056）
江苏省中医院2014年院级课题(Y14036) （Y14036）
