中成药2017，Vol.39Issue(12)：2503-2507,5.DOI:10.3969/j.issn.1001-1528.2017.12.011
漆黄素固体分散体的制备
Preparation of fisetin solid dispersions
摘要
Abstract
AIM To prepare fisetin solid dispersions.METHODS Melting method and solvent method were used for the preparation of solid dispersions,respectively.With carrier type,drug-carrier ratio and stirring time as influencing factors,accumulative dissolution rate as an evaluation index,the preparation was optimized by orthogonal test on the basis of single factor experiment.The interaction between drug and carrier was investigated by Fourier transform infrared spectroscopy (FTIR),and the drug existing state was analyzed by differential scanning calorimetry (DSC).RESULTS Solvent method was more suitable for the preparation of solid dispersions.The optimal conditions were determined to be PVPK-30 as a carrier,1 ∶ 12 for drug-carrier ratio,and 30 min for stirring time,the accumulative dissolution rate reached 90.87％ within 20 min.There might be a hydrogen bond association between PVPK-30 and fisetin previously existing in amorphous or molecular state.CONCLUSION The dissolution rate of fisetin can be obviously increased after being prepared into solid dispersions.关键词
漆黄素/固体分散体/制备/正交试验/傅里叶红外光谱/差示扫描量热Key words
fisetin/solid dispersions/preparation/orthogonal test/Fourier transform infrared spectroscopy/differential scanning calorimetry分类
医药卫生引用本文复制引用
冯春来,丁洋洋,李文静,余剑吟,徐希明..漆黄素固体分散体的制备[J].中成药,2017,39(12):2503-2507,5.基金项目
国家自然科学基金(81373897) （81373897）
江苏省博士后科研基金(1402174C) （1402174C）
江苏大学高级专业人才科研启动基金(12JDG034) （12JDG034）
