中成药2017，Vol.39Issue(12)：2546-2550,5.DOI:10.3969/j.issn.1001-1528.2017.12.021
尖叶假龙胆化学成分的研究
Chemical constituents from Gentianella acuta
摘要
Abstract
AIM To study the chemical constituents from Gentianella acuta (Michx.) Hulten.METHODS The 30％ and 90％ ethanol fractions of 70％ ethanol extract from G.acuta were isolated and purified by silica,ODS and preparative HPLC column,then the structures of obtained compounds were identified by spectral data.RESULTS Nine compounds were isolated and identified as sinenoside Ⅰ (1),(+)-lariciresinol-4,4'-0-bis-β-D-glucopyranoside (2),(+)-8-hydroxylariciresinol-4'-O-β-D-glucopyranoside (3),(+)-lariciresinol-4-O-3-D-glucopyranoside (4),(7S,8R)-erythro-7,9,9'-trihydroxy-3,3'-dimethoxy-8-O-4'-neolignan-4-O-β-D-glucopyranoside (5),(7S,8R)-erythro-4,9,9'-trihydroxy-3,3'-dimethoxy-8-O-4'-neolignan-7-O-β-D-glucopyranoside (6),(7S,8R)-erythro-4,7,9-trihydroxy-3,3'-dimethoxy-8-O-4'-neolignan-9'-O-β-D-glucopyranoside (7),balanophonin (8),urolignoside (9).CONCLUSION Compounds 2-9 are isolated from genus Gentianella for the first time.关键词
尖叶假龙胆/化学成分/分离鉴定Key words
Gentianella acuta (Michx.) Hulten/chemical constituents/isolation and identification分类
医药卫生引用本文复制引用
匡海学,王斌,吴倩倩,吴高松,于莹,陈亚军,王秋红,杨炳友,王知斌..尖叶假龙胆化学成分的研究[J].中成药,2017,39(12):2546-2550,5.基金项目
国家重点基础研究发展计划-973计划(2013CB531801) （2013CB531801）
教育部博士点基金项目(20132327120002) （20132327120002）
黑龙江中医药大学“优秀创新人才”支持项目(2012RCD05) （2012RCD05）
黑龙江中医药大学“杰出人才培养”基金项目(2012cj02) （2012cj02）
