浙江医学2017，Vol.39Issue(21)：1852-1855,1859,5.DOI:10.12056/j.issn.1006-2785.2017.39.21.2017-1605
川崎病休克综合征临床特征及外周血细胞因子水平分析
Clinical characteristics and serum cytokine levels in patients with Kawasaki disease shock syndrome
李艳蝶 1郭莉 1邹丽霞 1滕丽萍 1郑嵘君 1徐益萍 1卢美萍1
作者信息
- 1. 310003杭州,浙江大学医学院附属儿童医院风湿免疫过敏科
- 折叠
摘要
Abstract
Objective To investigate the clinical characteristics and serum cytokine levels in children with Kawasaki disease shock syndrome (KDSS).Methods Seventeen KDSS children and 43 age-and gender-matched patients with Kawasaki disease (KD) admitted during January 2014 to December 2016 were included in this study.Serum levels of interleukin-2(IL-2),IL-4,IL-6,IL-10,tumor necrosis factor-α (TNF-α),and interferon gamma (IFN-γ) were measured by flow cytometry in two groups.The clinical characteristics,serum cytokine levels and routine laboratory parameters,the liver,kidney and blood coagulation functions and disease outcomes were compared between two groups.Results Compared with KD group,the duration of fever and length of hospital stay in KDSS group were significantly prolonged,the WBC,neutrophil,ESR and serum CRP,creatinine,urea nitrogen,D-dimer,IL-6,IL-10,TNF-α IFN-γ.levels were elevated,the incidence of coronary artery lesions,intravenous immunoglobulin (IVIG) resistance,admission to ICU and other organ damage were significantly increased (all P＜0.05),while blood hemoglobin,albumin,sodium and potassium concentrations were significantly decreased (all P＜0.05).No deaths were found in two groups.Conclusion Increased levels of IL-6,IL-10,TNF-oα,IFN-γ and IVIG resistance leading to persistent inflammation may be involved in the development of KDSS.The duration of fever and hospital stay are prolonged,the conditions are more serious and more susceptible to coronary and other organ damage in patients with KDSS.关键词
川崎病休克综合征/临床特征/细胞因子Key words
Kawasaki disease shock syndrome/Clinical characteristics/Cytokine引用本文复制引用
李艳蝶,郭莉,邹丽霞,滕丽萍,郑嵘君,徐益萍,卢美萍..川崎病休克综合征临床特征及外周血细胞因子水平分析[J].浙江医学,2017,39(21):1852-1855,1859,5.
