浙江医学2017，Vol.39Issue(21)：1868-1871,4.DOI:10.12056/j.issn.1006-2785.2017.39.21.2017-1608
涎腺超声联合血清BAFF检测在原发性干燥综合征诊断中的价值
Serum BAFF test combined with salivary gland ultrasonography in diagnosis of primary Sjogren's syndrome
摘要
Abstract
Objective To assess the value of serum BAFF level combined with salivary gland ultrasonography in diagnosis of primary Sjogren's syndrome (pSS).Methods The serum levels of BAFF,APRIL,TNF-a,IL-1 β and IL-6 were measured by ELISA in 80 pSS patients,60 rheumatoid arthritis(RA) patients and 60 healthy controls.Salivary gland was examined with two-dimensional ultrasonography in three groups.The correlation of serum levels of BAFF,APRIL,TNF-α,IL-1 β,IL-6 and salivary gland ultrasonography with pSS was evaluated.Results The serum levels of BAFF,IL-1 β,TNF-o in pSS patients were significantly higher than those in RA patients and healthy controls (all P＜0.05),while there were no significant differences in serum levels of APRIL and IL-6 among tree groups.The salivary gland ultrasound scores was negatively correlated with serum BAFF level (r=-0.462,P＜0.05) and positively correlated with IL-1 β level (r=0.403,P＜0.05).The sensitivity of salivary ultrasonography in diagnosis of pSS was higher than that of SSA/SSB and the specificity was similar.The sensitivity of serum BAFF in diagnosis of pSS was higher than that of SSA/SSB,but the specificity was lower.For pSS patients with ultrasonic score ＜ 2min,the specificity of ultrasonography combined with BAFF was increased to 96.77％.Conclusion Serum BAFF measurement combined with salivary gland ultrasound examination can be used for screening and diagnosis of primary Sjogren's syndrome.关键词
B淋巴细胞刺激因子/涎腺超声/原发性干燥综合征Key words
B cell activating factor/Salivary gland ultrasonography/Primary Sjogren's syndrome引用本文复制引用
耿保庆,黄娴倩,干敏芝,彭勇,朱梦雅,应颖,黄海燕,陈勇..涎腺超声联合血清BAFF检测在原发性干燥综合征诊断中的价值[J].浙江医学,2017,39(21):1868-1871,4.基金项目
2017年宁波市自然基金(2017A610208) （2017A610208）
