浙江医学2017，Vol.39Issue(21)：1895-1897,1900,4.DOI:10.12056/j.issn.1006-2785.2017.39.21.2017-1612
强直性脊柱炎患者血清及关节液中S100A8/9水平变化及意义
Clinical significance of S100A8/9 levels in serum and synovial fluid of patients with ankylosing spondylitis
摘要
Abstract
Objective To investigate the clinical significance of S100A8/9 levels in serum and synovial fluid of patients with ankylosing spondylitis (AS).Methods Fifty five patients with AS were included in the study,including 19 cases of active AS and 36 cases of non-active AS according to Bath Ankylosing Spondylitis Disease Activity Index(BASDAI) median (3.1),and 20 healthy subjects served as the control group.The levels of S100A8/9 in serum and synovial fluid were measured by ELISA assay before and after the treatment.The level of S100A8/9,CRP and ESR were compared in the three groups.The correlation between S100A8/9 and BASDAI was analyzed.Results Serum S100A8/9 levels in 55 patients with AS were significantly higher than those in controls (P＜0.01).The S100A8/9 levels in synovial fluid from 15 AS patients were significantly higher than those in serum (P＜ 0.01).The serum levels of S100A8/9,CRP and ESR in active AS patients were significantly higher than those in non-active AS patients (all P＜0.01).After three months of treatment,the serum levels of S100A8/9 and BASDAI from 19 patients with active diseases were significantly decreased.Serum levels of S100A8/9 in 55 AS patients were positively correlated with BASDAI (r=0.336,P＜0.05),but not correlated with CRP and ESR levels((r=0.051 and 0.067,both P＞0.05).Conclusion Serum S100A8/9 levels are associated with active disease in AS patients,indicating that serum S100A8/9 levels might be a potential marker for disease activity in AS.关键词
强直性脊柱炎/S100A8/9/疾病活动度Key words
Ankylosing spondylitis/S100A8/9/Disease activity引用本文复制引用
陈士芳,许瑜佳,殷丽娟,陶渊缪,梅珏,王友庆..强直性脊柱炎患者血清及关节液中S100A8/9水平变化及意义[J].浙江医学,2017,39(21):1895-1897,1900,4.基金项目
湖州市科学技术局项目(2016GYB24) （2016GYB24）
