中国中西医结合杂志2017，Vol.37Issue(10)：1174-1180,7.DOI:10.7661/j.cjim.20170908.369
基于陈可冀院士血瘀证辨证方法治疗冠心病稳定性心绞痛的实用性随机对照研究
Pragmatic Randomized Controlled Trial on Treating Stable Angina Pectoris of Coronary Heart Disease Based on Chen Ke-ji's Pattern Identification Methods of Blood-Stasis Syndrome
摘要
Abstract
Objective To evaluate the effectiveness and safety of treatment based on "Chen Ke-ji's pattern identification (PI) methods of blood stasis syndrome (BSS)" for stable angina pectoris of coronary heart diseae.Methods Totally 300 patients with stable angina pectoris were randomly assigned to the experimental group and the control group using pragmatic randomized controlled trial (PRCT),150 cases in each group.All patients received routine Western medical treatment.Patients in the experimental group additionally took "Chen Ke-ji's PI methods of BSS "-guided treatment.Meanwhile,patients in the control group received "conventional diagnostic criterion of BSS"-guided treatment.The treatment lasted for four successive weeks.The primary outcomes (including BSS scores and scores of angina symptoms),secondary outcomes [including reduction of nitroglycerin,Seattle Angina Questionnaire (SAQ) scores and hemorrheology indexes] and adverse reactions were observed before and after treatment.Results Totally 253 cases were available,127 in the experimental group and 126 in the control group.Compared with before treatment,BSS scores,scores of angina symptoms,and rheology indexes of blood in both groups were statistically reduced in both groups,as well as SAQ scores was improved in both groups (P ＜0.01,P ＜0.05).Better effect in improving angina scores,SAQ scores,and the reduction level of blood viscosity (120 s-1)were obtained in the experimental group compared with the control group after treatment (P ＜0.05).No adverse reaction occurred in the two groups during the treatment course.Conclusion Treatment based on "Chen Ke-ji's PI methods of BSS" was effective and safe in patients with stable angina pectoris,and had certain advantages compared with treatment based on "conventional diagnostic methods of BSS".关键词
陈可冀/血瘀证/冠心病/辨证论治/实用性随机对照试验Key words
Chen Ke-ji/blood stasis syndrome/coronary heart disease/syndrome differentiation and treatment/pragmatic randomized controlled trial引用本文复制引用
王安璐,徐浩,史大卓,陈可冀,罗静,于美丽,高翔,张贺,寇娜,车方远,陈卓,李金根..基于陈可冀院士血瘀证辨证方法治疗冠心病稳定性心绞痛的实用性随机对照研究[J].中国中西医结合杂志,2017,37(10):1174-1180,7.基金项目
“十二五”国家科技支撑计划项目(No.2013BAI13B01) （No.2013BAI13B01）
