中国中西医结合杂志2017，Vol.37Issue(10)：1191-1195,5.DOI:10.7661/j.cjim.20170821.200
基于因子分析与聚类分析对溃疡性结肠炎中医证候规律的研究
Study on the Chinese Medical Syndrome Types of Ulcerative Colitis Based on Factor Analysis and Cluster Analysis
摘要
Abstract
Objective To explore the characteristics of traditional Chinese medicine (TCM) syndrome classification and the distribution pattern of syndrome types in ulcerative colitis.Methods Diagnostic information was collected from 441 cases of ulcerative colitis patients.The general situation,combined with clinical data of disease,TCM syndrome,tongue information were investigated using self-made "ulcerative colitis TCM syndrome epidemiology questionnaire",and analyzed by factor analysis and cluster analysis method.Results Factor analysis was used to analyze the 58 syndrome entries,and the KMO statistic was 0.916,Bartlett ball type test P ＜0.0001.A total of 13 common factors were extracted and 46 significant symptoms were screened out by the maximum likelihood estimation method.According to the disease nature and location,the basic TCM syndromes of ulcerative colitis were divided into 6 categories.Cluster analysis showed that the proportion of syndrome types were as follows:the syndrome of Pi-Wei qi deficiency was 27.66％ (122/441),the syndrome of large intestine dampness-heat was 26.30％ (116/441),the syndrome of Pi-Shen yang deficiency was 17.69％ (78/441),the syndrome of Gan depression Pi deficiency was 15.65％ (69/441),the syndrome of yin deficiency and intestinal dryness was 8.39％ (37/441),and the syndrome of blood stasis and intestinal collaterals was 4.31％ (19/441).In addition,the distribution of TCM syndromes in different stage and clinical type were analyzed,which the syndrome of large intestine dampness-heat accounted for 48.00％ (108/225) during the activity period,the syndrome of Pi-Wei qi deficiency was 41.20％ (89/216) in the remission stage,the syndrome of large intestine dampness-heat accounted for 53.55％ (83/155) in first episode types,the syndrome of Pi-Wei qi deficiency accounted for 45.11％ (60/133) in chronic recurrence types,the syndrome of Pi-Shen yang deficiency accounted for 40.52％ (47/116) in chronic persistent types,and the other syndromes were similar in distribution.Conclusions The basic TCM syndromes of ulcerative colitis show 6 categories.Among them,the syndrome of UC in active stage was mainly large intestine dampness-heat,and the syndrome of Pi-Wei qi deficiency was the main type of UC remission stage.The first episode type of UC was mainly the syndrome of large intestine dampness heat,the chronic recurrence type was mainly the syndrome of Pi-Wei qi deficiency,and the chronic persistent type was mainly the syndrome of Pi-Shen yang deficiency.关键词
溃疡性结肠炎/中医证候/因子分析/聚类分析Key words
ulcerative colitis/Chinese medical syndrome type/factor analysis/cluster analysis引用本文复制引用
李毅,樊新荣,刘力,刘艳,王捷虹,王小平..基于因子分析与聚类分析对溃疡性结肠炎中医证候规律的研究[J].中国中西医结合杂志,2017,37(10):1191-1195,5.基金项目
国家自然科学基金资助项目(No.81173156) （No.81173156）
陕西省科技厅研究资助项目(No.2013JQ4009) （No.2013JQ4009）
陕西省教育厅研究资助项目(No.2014JK1200) （No.2014JK1200）
