Abstract
Objective To observe the clinical efficacy of anti-tuberculosis therapeutic regimen with Feitai Capsule (FC) in the treatment of retreated pulmonary tuberculosis (TB).Methods Totally 113 retreated TB patients were assigned to the treatment group (58 cases) and the control group (55 cases) by random digit table.All patients received routine anti-tuberculosis chemotherapy (3H-R-Z-E/6H-R-E).Those in the treatment group took FC 2.5 g each time,3 times per day.The therapeutic course for all was 9 months.Sputum negative conversation rates after 2,5,8 months,foci absorption and void closure rates after 3,6,9 months,clinical symptoms remission rates after 1 month,and incidence of adverse reactions after 9 months were detected.Results After 2,5,8 months of treatment,the sputum negative conversion rates were 75.00％ (21/28),92.86％ (26/28),96.43％ (27/28) in the treatment group,obviously higher than those of the control group [41.67％ (10/24),70.83％ (17/24),75.00％ (18/24),x2 =5.96,4.92,5.09,P ＜0.05].After 3,6,9 months of treatment,the total foci absorption rates were 81.03％ (47/58),94.83％ (55/58),98.28％ (57/58) in the treatment group,significantly higher than those of the control group [43.64％ (24/55),61.82％ (34/55),70.91％ (39/55)],x2 =16.91,18.39,16.54,all P ＜0.01].And the total void closure rates were [70.00％ (28/40),87.50％ (35/40),95.0％(38/40)] in the treatment group,significantly higher than those of the control group [27.03％ (10/37),48.65％ (18/37),70.27％ (26/37),x2 =14.20,13.52,8.38,P ＜0.01].The remission rates of cough,expectoration,hemoptysis,fever,fatigue,night sweat and anorexia in the treatment group were all higher than those of the control group (x2 =4.78,5.59,5.40,4.65,4.25,4.79,4.50,P ＜0.05) after 1 month of treatment.The incidence of adverse reactions in the treatment group was 24.13 ％ (14/58),and 29.09％ (16/55) in the control group,with no statistical difference between the two groups(x2 =0.36,P ＞0.05).Conclusions Using FC with anti-TB chemotherapeutic drugs to treat retreated TB could effectively improve foci absorption,cavities closure and sputum conversation.关键词
肺泰胶囊/抗结核治疗/复治肺结核/临床疗效Key words
Feitai Capsule/anti-tuberculosis therapy/retreated pulmonary tuberculosis/clinical effects
