摘要
Abstract
Objective To explore the effect of Cordyceps militaris polysaccharides ( CMP ) on subacute liver injury in mice induced by alcohol. Method ICR mice were randomly divided into four groups:normal control group,ethanol injury model group,CMP low dose group (0. 25 g/kg),and CMP high dose group (0. 5 g/kg). Except for the normal control group,other three groups were given 30％ ethanol 12 mL/kg respectively. After 6 hours of intragastric administration of ethanol, the corresponding dose of CMP were given to the mice in CMP group,the control group and the model group were given saline at the same time. After 28 days,all the mice were sacrificed and the serum alanine aminotransferase (ALT),aspartate aminotransferase(AST),total protein (TP), albumin (ALB),serum globulin (GLO),triglyceride (TG),total cholesterol (CHOL) were detected according to the corresponding kit. The liver of each mouse was taken out and calculated its index. Results Compared with the control group,the liver coefficients,serum ALT,AST,TG and CHOL increased in the model group,while the levels of serum TP ,ALB and GLO decreased. CMP could significantly reduce the hepatic organ coefficient,reduce the activities of serum ALT and AST,and the levels of TG and CHOL,increased the contents of serum TP ,ALB and GLO in alcohol-induced liver injury in mice. Conclusion Cordyceps militaris polysaccharide can significantly improve the alcohol-induced liver injury and has a certain protective effect on liver in mice.关键词
蛹虫草多糖/酒精/亚急性肝损伤/肝功能Key words
Cordyceps militaris polysaccharide/alcohol/subacute liver injury/liver function分类
医药卫生
