重庆医学2018，Vol.47Issue(1)：60-62,3.DOI:10.3969/j.issn.1671-8348.2018.01.021
结直肠癌组织中同源异型盒基因B7蛋白的表达及临床意义
Expression of HOXB7 protein in colorectal cancer and its clinical significance
罗云春 1易文 1姚宇宙 1朱妮 1覃鹏飞1
作者信息
摘要
Abstract
Objective To investigate the expression of HOXB7 in colorectal cancer and its relationship with clinicopathological factors and prognosis.Methods Eighty-seven patients with colorectal cancer were retrospectively analyzed.The expression of HOXB7 mRNA and protein in colorectal cancer tissues was detected by RT-PCR and immunohistochemical methods.Their correlation with clinicopathological parameters and prognosis was analyzed.Results The relative expression level of HOXB7 mRNA in colorectal cancer tissue was(42.4 ± 16.3),which was significantly higher than(19.4 ± 7.6) in the paracancerous normal tissue(P＜0.05).The positive expression rate of HOXB7 protein in colorectal cancer tissues was 73.9％,which was obviously higher than 10.3 ％ in the paracancerous normal tissue (P＜ 0.05);expression of HOXB7 protein was significantly correlated with the TNM stage,lymph node metastasis and distant metastasis(P＜0.05),moreover the patients with HOXB7 positive expression had poorer prognosis.Conclusion HOXB7 protein expression is up-regulated in colorectal cancer tissue,and its high expression is correlated with the clinicopathological factors and prognosis in the patients with colorectal cancer.关键词
结直肠肿瘤/同源盒结构域蛋白质类/肿瘤转移/预后Key words
colorectal neolpasms/homeodomain proteins/neoplasm metastasis/prognosis分类
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罗云春,易文,姚宇宙,朱妮,覃鹏飞..结直肠癌组织中同源异型盒基因B7蛋白的表达及临床意义[J].重庆医学,2018,47(1):60-62,3.
