儿科药学杂志2018，Vol.24Issue(1)：16-18,3.DOI:10.13407/j.cnki.jpp.1672-108X.2018.01.006
匹多莫德对过敏性紫癜患儿外周血CD4+CD25+CD127-调节性T细胞的影响
Pidotimod on Peripheral Blood CD4+CD25+CD127-Regulatory T Cells of Children with Henoch-Sch(o)nlein Purpura
魏洪平 1吴敏 1吴莉萍1
作者信息
- 1. 温州医科大学附属义乌医院,浙江义乌322000
- 折叠
摘要
Abstract
Objective:To explore the influence of pidotimod on peripheral blood CD4+CD25+CD127-regulatory T cells in children with Henoch-Sch(o)nlein purpura (HSP).Methods:Eighty cases of HSP were selected and randomly divided into the treatment group and the control group,40 cases in each group.The control group was given the routine therapy,while the treatment group was added oral pidotimod granules on the basis of the routine therapy.The proportion of peripheral blood CD4+CD25+CD127-regulatory T cells and the serum of IL-10,IL-4 and INF-γlevels were tested before and after 2 weeks' treatment Results:The proportion of CD4+CD25+CD127-regulatory T cells in the treatment group was 3.85％ ±0.97％,which was significantly higher than the control group (2.54％ ±0.89％) after treatment (P＜0.01).The serum levels of IL-10 and IL-4 in the treatment group were (29.58±8.42) pg/mL and (76.47±16.45) ng/L,which were significantly lower than the control group ((40.89±9.67) pg/mL and (96.52±18.79) ng/L) after treatment (all P＜0.05).The serum level of INF-γ in the treatment group was (89.54± 15.87) ng/L,which was significantly higher than the control group ((77.43±15.32) ng/L) after treatment (P＜0.05).The INF-γ/IL-4 in the treatment group (1.17±±0.43) was significantly higher than the control group (0.81 ±0.32) after treatment (P＜0.01).Conclusion:Pidotimod can increase the proportions of CD4+CD25+CD127-regulatory T cells in the onset of HSP in children.It can relieve the inflammatory reaction and correct immune imbalance.关键词
匹多莫德/过敏性紫癜/外周血CD4+CD25+CD127-/调节性T细胞Key words
pidotimod/Henoch-Sch(o)nlein purpura/peripheral blood CD4 + CD25+ CD127-/regulatory T cells分类
医药卫生引用本文复制引用
魏洪平,吴敏,吴莉萍..匹多莫德对过敏性紫癜患儿外周血CD4+CD25+CD127-调节性T细胞的影响[J].儿科药学杂志,2018,24(1):16-18,3.
