法医学杂志2017，Vol.33Issue(6)：611-614,618,5.DOI:10.3969/j.issn.1004-5619.2017.06.009
江苏汉族人群30个插入/缺失位点的遗传多态性
Genetic Polymorphism of 30 InDel Loci in Han Population from Jiangsu Province
潘猛 1居晓斌 1刘燕婷 1崔鹤 1顾民 1周惠英1
作者信息
- 1. 南京医科大学第一附属医院 江苏省人民医院司法鉴定所,江苏 南京 210029
- 折叠
摘要
Abstract
Objective To investigate the genetic information of 30 insertion/deletion (InDel) loci in Han population from Jiangsu Province, and to explore the application values of Investigator? DIPplex kit for guiding the forensic analysis in Han population from Jiangsu Province. Methods The autosomal InDel loci of 305 unrelated healthy Han individuals from Jiangsu Province were genotyped and analysed by In-vestigator? DIPplex kit, and the allelic frequencies and forensic parameters of 30 InDel loci were statis-tically analysed. Results The distribution of 30 InDel loci in Han population from Jiangsu Province con-formed to Hardy-Weinberg equilibrium. The minor allele frequencies of 21 InDel loci were above 0.3. The polymorphism information content ranged from 0.089 to 0.375, while the discrimination power dis-tributed from 0.093 to 0.500. The paternity exclusion in duo cases and trio cases were 0.047-0.250 and 0.046-0.219, respectively. The linkage disequilibrium analysis of 30 InDel loci showed that all loci were independent from each other. The combined discrimination power was 1-7.369 ×10-8, whereas the com-bined mean exclusion chance in duo cases was 0.998933978, in trio cases was 0.997806392. The Fst values were all less than 0.06 except HLD118 and other four loci, which showed small differences be-tween groups. Conclusion The InDel loci of Investigator ? DIPplex kit can be used as complementary genetic markers for the cases associated with forensic genetics.关键词
法医遗传学/多态现象,遗传/插入/缺失/Investigator®DIPplex试剂盒/汉族/江苏Key words
forensic genetics/polymorphism/genetic/insertion/deletion/Investigator ® DIPplex kit/Han nationality/Jiangsu分类
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潘猛,居晓斌,刘燕婷,崔鹤,顾民,周惠英..江苏汉族人群30个插入/缺失位点的遗传多态性[J].法医学杂志,2017,33(6):611-614,618,5.
