中国妇幼健康研究2017，Vol.28Issue(12)：1695-1698,4.DOI:10.3969/j.issn.1673-5293.2017.12.061
影响高龄女性拮抗剂方案IVF-ET妊娠结局的多因素分析
Factors Related to Clinical Pregnancy Outcomes of In-vitro Fertilization-Embryo Transfer with GnRHAntagonist Protocol in Elderly Women
摘要
Abstract
Objective To investigate the factors related to clinical pregnancy outcomes of in vitro fertilization-embryo transfer (IVF-ET) with GnRH antagonist (GnRH-ant) protocol in elderly infertile women and to estimate the effect of these factors on clinical outcomes .Methods Retrospective analysis was performed on the clinical ,laboratory and follow-up data of 188 cycles in 179 elderly infertile patients who met the inclusion criteria undergoing IVF-ET in reproductive medicine center of Guangdong Women and Children Hospital from January 2015 to December 2016 ,and the patients were divided into two groups according to clinical pregnancy situation .The factors related to pregnancy outcome were analyzed by univariate methods .Results Among 188 cycles 56 cases (29 .79％ ) had clinical pregnancy and 132 cases (70 .21％ ) had no clinical pregnancy .After balancing the maternal ages of two groups ,there were significant differences in anti-Mulerian hormone (AM H) level (2 .66 ± 2 .55ng/mL vs 2 .21 ± 1 .67ng/mL ) ,Gn starting dose (260 .27 ± 58 .15IU vs 272 .35 ± 44 .26IU ) and LH level of the trigger day (3 .39 ± 1 .49U /L vs 3 .70 ± 2 .93U /L) between two groups (t value was 6 .50 , - 5 .53 and - 9 .56 ,respectively ,all P < 0 .05) .Conclusion Compared to maternal age ,AM H level is the more sensitive indicator to predict clinical pregnancy outcomes of the elderly women (38 - 43 years old) undergoing IVF-ET with GnRH antprotocol .The higher LH level of the trigger day is negative for clinical pregnancy ,and GnRH-ant dose should be increased in order to reduce LH level if necessary .关键词
不孕/高龄/体外受精-胚胎移植/拮抗剂方案/妊娠结局Key words
infertility/elderly women/in vitro fertilization-embryo transfer (IVF-ET )/GnRH antagonist protocol/pregnancy outcomes分类
医药卫生引用本文复制引用
齐诠,黄莉,李子涛,易艳红,刘风华..影响高龄女性拮抗剂方案IVF-ET妊娠结局的多因素分析[J].中国妇幼健康研究,2017,28(12):1695-1698,4.基金项目
广东省自然科学基金资助项目(项目编号:2016A030310318) （项目编号:2016A030310318）
