湖南中医药大学学报2018，Vol.38Issue(1)：13-16,4.DOI:10.3969/j.issn.1674-070X.2017.01.004
熊果酸对大鼠CIA模型关节TNF-α、IL-17、PGE2表达的影响
Effects of Ursolic Acid on the Expression of TNF-α, IL-17 and PGE2 in Joints of CIA Model Rats
摘要
Abstract
Objective To investigate the effect of ursolic acid (UA) on the expression of TNF-α, IL-17 and PGE2 in the joints of rats with collagen-induced arthritis (CIA). Methods Eight rats as normal control group were randomly selected from the 60 SD rats, and the other rats were built for CIA models. Then the CIA models were randomly divided into model control group, ursolic acid group, methotrexate group and dexamethasone group. The rats were sacrificed 35 days after the administration, and the sections were harvested for HE staining to observe the pathological changes of the joint bone. The expression of inflammatory cytokines TNF-α, IL-17 and PGE2 were detected by immunohistochemistry. Results Compared with CIA model group, the expression of inflammatory factors TNF-α, IL-17 and PGE2 in UA rats significantly decreased (P<0.01), and the effects of UA were not as good as those in methotrexate and dexamethasone groups (P<0.01). Conclusion UA can significantly relieve the inflammation and injury of joints in CIA rats and reduce the expression of related inflammatory factors in the joints.关键词
熊果酸/胶原诱导性关节炎/炎症因子/TNF-α/IL-17/PGE2Key words
ursolic acid/collagen-induced arthritis/inflammatory factors/TNF-α/IL-17/PGE2分类
医药卫生引用本文复制引用
曾光,陈芳,邵峰,夏帅帅,刘沙,鲜瑶瑶,周俭,黄惠勇..熊果酸对大鼠CIA模型关节TNF-α、IL-17、PGE2表达的影响[J].湖南中医药大学学报,2018,38(1):13-16,4.基金项目
国家自然科学基金青年项目(81403206) （81403206）
中国博士后基金委面上项目(2014M560646) （2014M560646）
湖南省科技厅社会发展项目(2014SK3042) （2014SK3042）
湖南省教育厅青年项目(2014B131) （2014B131）
湖南省研究生科研创新项目(CX2017B447) （CX2017B447）
湖南中医药大学青年项目(2014-43). （2014-43）
