湖南中医药大学学报2018，Vol.38Issue(1)：17-20,4.DOI:10.3969/j.issn.1674-070X.2018.01.005
青光安颗粒剂对自发型青光眼小鼠眼压的影响
Effect of Qingguangan Granules on Intraocular Pressure of Spontaneous Glaucoma Mice
摘要
Abstract
Objective Effect of Qingguangan Granule on intraocular pressure in glaucoma. Methods Thirty female DBA/2J mice were selected. The mice were randomly divided into three groups, the normal control group (three months old), model control group (nine months old), Qingguangan group (nine months old), 10 rats with 20 eyes in each group. The control group and model group were given same distilled water by gavage, and Qingguangan group was given Qingguangan granules. The three groups were administrated with conventional feed with the rate of 2.5 and 5 μL/min. The intraocular pressure was measured by anterior chamber injection/suction system, and the coefficient of aqueous outflow and outflow resistance were measured. Results The intraocular pressure of mice at six months olds increased slightly, and gradually increased with the increase of the months old, and increased significantly at nine months old (P<0.05). The intraocular pressure decreased in different degree compared with the model group after intragastric administration of Qingguangan granules (P<0.01). The co-efficient of aqueous humor increased significantly and outflow resistance decreased (P<0.01). Conclusion Qingguangan Granules can reduce glaucoma intraocular pressure through affecting aqueous humor dynamics.关键词
青光安/青光眼/眼压/房水动力学Key words
Qingguangan granules/glaucoma/intraocular pressure/aqueous humor dynamics分类
医药卫生引用本文复制引用
项宇,刘家琪,李萍,彭俊,刘晓清,汤杰,喻娟,龙达,彭清华..青光安颗粒剂对自发型青光眼小鼠眼压的影响[J].湖南中医药大学学报,2018,38(1):17-20,4.基金项目
国家自然科学基金资助项目(81403437,81603665) （81403437,81603665）
湖南省高层次卫生人才"225"工程培养项目资助 （）
中国博士后基金面上资助项目(2015M570681) （2015M570681）
湖南省自然科学基金资助项目(2015JJ3097) （2015JJ3097）
湖南省教育厅科研基金优秀青年资助项目(14B137) （14B137）
湖南省研究生创新基金重点资助项目(CX2013A013) （CX2013A013）
国家中医药管理局中医眼科学重点学科建设项目 （）
湖南省中医五官科学重点学科建设项目. （）
