湖南中医药大学学报2018，Vol.38Issue(1)：40-42,3.DOI:10.3969/j.issn.1674-070X.2018.01.010
血浆miR-200c作为肺癌早期诊断的临床价值研究
Clinical Value of Plasma miR-200c in Early Diagnosis of Lung Cancer
摘要
Abstract
Objective To analyze the correlation between plasma miR-200c expression and clinicopathological features of lung cancer patients, and to explore the possibility of miR-200c as a potential tumor marker for early diagnosis of lung can-cer. Methods Fifty lung cancer patients and fifty-three healthy subjects, the expression of miR-200c in plasma was detected by real-time fluorescent quantitative PCR, and the results were statistically analyzed. Results MiR-200c expression in lung cancer patients were higher than that in normal control group and the difference was statistically significant (P<0.01). The re-ceiver operating characteristic curve showed that miR-200c expression was able to differentiate lung cancer from the normal control group (AUC=0.676). Conclusion The expression of miR-200c in plasma may be related to the occurrence of lung can-cer, suggesting that miR-200c may be a specific biomarker in patients during early diagnosis.关键词
肺癌/miR-200c/实时荧光定量PCR/早期诊断Key words
lung cancer/miR-200c/real time PCR/early diagnosis分类
医药卫生引用本文复制引用
王瑛琨,贾冬冬,刘琼,窦宇红,徐志康,刘和录..血浆miR-200c作为肺癌早期诊断的临床价值研究[J].湖南中医药大学学报,2018,38(1):40-42,3.基金项目
深圳市宝安区科技创新局社会公益项目(2014208). （2014208）
