湖南中医药大学学报2018，Vol.38Issue(1)：85-88,4.DOI:10.3969/j.issn.1674-070X.2017.01.022
银杏达莫注射液联合醋酸泼尼松治疗突发性耳聋患者疗效观察及其对患者血液流变学和细胞因子影响
Clinical Effect of Ginkgo-Damole Injection Combined with Prednisone Acetate on Hemorheology and Cytokines in Patients with Sudden Deafness
摘要
Abstract
Objective To explore the effect of ginkgo-damole injection combined with prednisone acetate in treatment of patients with sudden deafness, hemorheo logy and serum inflammatory cytokines of patients before and after treatment were observed. Methods 102 cases of patients (102 eyes) with sudden deafness were randomly divided into the control group and observation group, 51 cases (51 eyes) in each group. The control group was treated with acetic acid prednisone, the observation group was given with ginkgo biloba injection on the basis of the control group. Therapeutic effect of the two groups was observed. The plasma viscosity (PV), hematocrit (HCT), erythrocyte aggregation index (EAI) and cytokines neutrophil activation peptide (ENA-78), the high mobility of serum protein 1 (HMGB1) levels and the incidence of adverse events during treatment were recorded. Results The effective rate of observation group was 94.12％, higher than 76.47％ in the control group, and the difference was statistically significant (P<0.05). After treatment for one week, ENA-78 of two groups was lower than before treatment;ENA-78, HMGB after treatment for two weeks were lower than before treatment, and the observation group was lower than control group (P<0.05). The indicators of the two groups after treatment for one week and two weeks decreased siginificantly, and after treatment for two weeks, PV, HCT, EAI of observation group were lower than the control group, the difference was statistically significant (P<0.01). The incidence of adverse events in the observation group was 5.88％, compared with 1.96％ in the control group (P>0.05). Conclusion Ginkgo-damole injection combined with prednisone acetate could improve the blood rheology and chemokine levels of patients with sudden deafness. It is worth clinical promotion.关键词
突发性耳聋/银杏达莫注射液/醋酸泼尼松Key words
sudden deafness/ginkgo-damole injection/prednisone acetate分类
医药卫生引用本文复制引用
黄芳,蒋玉欢,郭飞波,郑志刚..银杏达莫注射液联合醋酸泼尼松治疗突发性耳聋患者疗效观察及其对患者血液流变学和细胞因子影响[J].湖南中医药大学学报,2018,38(1):85-88,4.基金项目
湖北省医学科技攻关计划项目(201403209). （201403209）
