中医药导报2018，Vol.24Issue(1)：84-88,95,6.
中西医结合治疗耐多药肺结核随机对照试验的Meta分析
Combined Traditional Chinese and Western Medicine Treatment for Multidrug-Resistant Pulmonary Tuberculosis: A Meta-Analysis of Randomized Controlled Trials
摘要
Abstract
Objective:To evaluate the efficacy and safety of combined Traditional Chinese Medicine and western medicine treatment for multidrug-resistant pulmonary tuberculosis (MDR-PTB).Methods:We searched PubMed,CNKI,CBM,Wanfang database and Technology journal database for randomized clinical trials (RCTs) published from inception to October 2016.Literature was screened according to inclusive and exclusive criteria,data were extracted and quality was assessed for each trial by two authors independently,and then Meta-analysis was performed using RevMan (version 5.3).Results:There were 45 RCTs included in quantitative analysis,involving 4,656 participants with MDR-PTB in total.The results showed that combined Traditional Chinese Medicine and western medicine treatment for MDR-PTB was superior to chemotherapy alone in terms of sputum bacteriological conversion rate [RR=1.30,95％ CI(1.22,1.39),P＜0.000,01],lung lesions resorption rate [RR=1.08,95％CI(1.01,1.14),P＜0.000,01],syndrome improvement rate [RR=1.23,95％CI(1.17,1.29),P＜0.000,01],lung cavity closure rate [RR=1.26,95％CI(1.17,1.35),P＜0.000,01] and total effective rate [RR=1.30,95％CI(1.21,1.39),P＜0.000,01] after initiation of treatment.In addition,adverse effects of combined Traditional Chinese Medicine and western medicine treatment for MDR-PTB were less than that of chemotherapy alone [RR =0.65,95％ CI(0.58,0.74),P＜0.000,01].Conclusion:Combined Traditional Chinese Medicine and western medicine treatment showed beneficial effect for MDR-PTB compared to chemotherapy alone.However,due to poor methodological reporting of the included trials,a confirmative conclusion needs to be supported by further robust clinical trials.关键词
中西医结合/肺结核/耐多药结核病/Meta分析/随机对照试验Key words
combined Traditional Chinese Medicine and western medicine/pulmonary tuberculosis/multidrug-resistant tuberculosis/Meta-analysis/randomized controlled trials分类
医药卫生引用本文复制引用
金昕,谢和宾,曾鸿,刘艳科,张婷,曹仕鹏,尹柯..中西医结合治疗耐多药肺结核随机对照试验的Meta分析[J].中医药导报,2018,24(1):84-88,95,6.基金项目
“十二五”科技重大专项-艾滋病和病毒性肝炎等重大传染病防治:中药多方多途径治疗多耐药及广泛耐药肺结核临床研究与方案筛选(2013ZX10005004) （2013ZX10005004）
