吉林中医药2018，Vol.38Issue(1)：41-44,4.DOI:10.13463/j.cnki.jlzyy.2018.01.012
丹参川芎嗪联合综合干预对慢性阻塞性肺疾病急性加重期合并呼吸衰竭患者炎性反应及肺功能的影响
Effect of Salvia miltiorrhiza and Ligustrazine combined intervention on inflammatory response and pulmonary function in patients with AECOPD complicated with RF
摘要
Abstract
Objective To investigate the effect of Salvia miltiorrhiza and Ligustrazine combined intervention on inflammatory response and pulmonary function in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated with respiratory failure (RF).Methods 110 patients with AECOPD combined with RF were divided into the observation group and the control group according to the random number table method, each with 55 cases, The control group was given conventional treatment, such as anti infection, bronchiectasis, expectorant, cough, asthma and nutritional support. The observation group was given Salvia miltiorrhiza and ligustrazine intravenous drip on the basis of the control group. The 2 groups were treated by comprehensive intervention after 10 d treatment. The radial artery blood was collected before and after treatment. The arterial carbon dioxide partial pressure (PaCO2), arterial oxygen partial pressure (PaO2) and arterial oxygen saturation (SaO2) were measured by blood gas analyzer; The peripheral venous blood from the morning was collected. Serum C reactive protein (CRP) was measured by immunoturbidimetry. Serum tumor necrosis factor alpha (TNF- alpha), interleukin -6 (IL-6) and interleukin -8 (IL-8) were measured by enzyme-linked immunosorbent assay (ELISA); Before and after treatment, the lung function (FVC), the first second forced expiratory volume (FEV1) and the maximum expiratory flow (PEF) were detected by the pulmonary function instrument.Results The PaCO2 of the observation group was lower than that of the control group after treatment. PaO2 and SaO2 were higher than those of the control group (P<0.05). After treatment, TNF-, CRP, IL-6 and IL-8 in the observation group were lower than those in the control group (P<0.05), and the FVC, FEV1 and PEF in the observation group were higher than those in the control group.Conclusion Comprehensive intervention can effectively improve the negative emotions of patients with AECOPD combined with RF, and make them better cooperate with the treatment. Salvia miltiorrhiza and Ligustrazine can effectively reduce the inflammatory response, improve blood gas index, and effectively promote the recovery of lung function.关键词
丹参川芎嗪/综合干预/慢性阻塞性肺疾病/呼吸衰竭/炎性反应/肺功能Key words
Salvia miltiorrhiza and Ligustrazine/comprehensive intervention/chronic obstructive pulmonary disease/acute exacerbation/respiratory failure/inflammatory reaction/pulmonary function分类
医药卫生引用本文复制引用
冯云霞,侯佳倩..丹参川芎嗪联合综合干预对慢性阻塞性肺疾病急性加重期合并呼吸衰竭患者炎性反应及肺功能的影响[J].吉林中医药,2018,38(1):41-44,4.基金项目
河北省科技攻关计划项目(1521055D). （1521055D）
