吉林中医药2018，Vol.38Issue(2)：201-205,5.DOI:10.13463/j.cnki.jlzyy.2018.02.024
甲炎康泰颗粒制备工艺研究
Study on the preparation technology of Jiayan Kangtai granule
摘要
Abstract
Obiective To determine the feasible preparation technology of the Jiayan Kangtai granule. Methods The best molding process of granules was studied by the factors of formability, fluidity, solubility and hygroscopicity. Results The optimum water extraction process of Prunella vulgaris was adding 15 times of water, extracting for 3 times, 2 hours each time, the extract was concentrated to a relative density of 1.05 (50～60 C) and deposited overnight with 70％ ethanol. The best alcohol extraction process of Radix Bupleuri and other drugs was adding 6 times amount of 80％ ethanol, extracting 3 times, 1 h each time. The extract was concentrated to dry, crushed, supplemented by 1:1～1:1.5, and added dextrin-lactose 3:1 as excipient, added 1％ aspartame as flavoring agent, with 80％ ethanol as a wetting agent. Conclusion The obtained process is reasonable and feasible, and the quality of preparation is stable. It provides scientific basis for the determination of granulation process and production environment control of Jiangyan Kangtai granule.关键词
桥本氏甲状腺炎/复方颗粒/制备工艺/迷迭香酸/柴胡皂苷Key words
Hashimoto' s thyroiditis/compound granule/preparation technology/rosmarinic acid/saikoside分类
医药卫生引用本文复制引用
石浩霞,刘铜华,徐云玲,解生旭,徐雅娟,李博,高佳琪,魏颖,王东超,徐暾海..甲炎康泰颗粒制备工艺研究[J].吉林中医药,2018,38(2):201-205,5.基金项目
科学技术部国际科技合作项目 (2015DFA30910):中药干预桥本氏甲状腺炎活性筛选技术与组方优化研究 （2015DFA30910）
北京中医药大学创新团队 - 中医药干预糖尿病及其并发症研究团队 (2011-CXTD-19). （2011-CXTD-19）
